Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1786847 | 0.83 | ATR (0.35) | GRIN1GRIN2BATR | |
| SCHEMBL25017779 | 0.79 | GRIN1 (0.30) | GRIN1GRIN2B | |
| SCHEMBL7649809 | 0.79 | S1PR1 (0.34) | GRIN1GRIN2B | |
| SCHEMBL19969081 | 0.78 | NOTUM (0.37) | NOTUM | |
| SCHEMBL7602053 | 0.77 | ELANE (0.33) | — | |
| SCHEMBL13856441 | 0.77 | NOTUM (0.42) | NOTUMEPHX2 | |
| SCHEMBL19229031 | 0.77 | BRD4 (0.30) | — | |
| SCHEMBL11325095 | 0.77 | ALDH1A1 (0.42) | NOTUMGRIN1GRIN2B | |
| SCHEMBL19969061 | 0.77 | POLB (0.43) | NOTUMATR | |
| SCHEMBL12299809 | 0.76 | MAPT (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11352344-B2 | Antagonists of the muscarinic acetylcholine receptor M4 | VANDERBILT UNIVERSITY (US) | 2022-06-07 | — | — | US | disclosed |
| US-20200339547-A1 | ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY | 2020-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200339547-A1 | ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | CHRM2, CHRM3, CHRM4 | NOTUM 934/4885GRIN1 91/4885GRIN2B 146/4885 |
| US-11352344-B2 | Antagonists of the muscarinic acetylcholine receptor M4 | CHRM2, CHRM3, CHRM4 | NOTUM 1092/4885GRIN1 84/4885GRIN2B 112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.