Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.61 |
| ▸ | TSHR | P16473 | 7/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PDE8B | O95263 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19914331 | 0.96 | ALDH1A1 (0.66) | ALDH1A1TSHRKMT2AMEN1L3MBTL1 | |
| SCHEMBL30867245 | 0.85 | ALDH1A1 (0.61) | ALDH1A1TSHRKMT2AMEN1L3MBTL1 | |
| SCHEMBL30867243 | 0.83 | ALDH1A1 (0.72) | ALDH1A1TSHRKMT2AMEN1L3MBTL1 | |
| SCHEMBL21163171 | 0.82 | ALDH1A1 (0.65) | ALDH1A1TSHRKMT2AMEN1L3MBTL1 | |
| SCHEMBL17069030 | 0.82 | ALDH1A1 (0.67) | ALDH1A1TSHRKMT2AMEN1L3MBTL1 | |
| SCHEMBL30867228 | 0.82 | ALDH1A1 (0.58) | ALDH1A1TSHRKMT2AMEN1L3MBTL1 | |
| SCHEMBL22601722 | 0.82 | ALDH1A1 (0.58) | ALDH1A1TSHRKMT2AMEN1L3MBTL1 | |
| SCHEMBL30867236 | 0.79 | ALDH1A1 (0.55) | ALDH1A1TSHRKMT2AMEN1L3MBTL1 | |
| SCHEMBL23248002 | 0.78 | ALDH1A1 (0.54) | ALDH1A1TSHRKMT2AMEN1L3MBTL1 | |
| SCHEMBL22602035 | 0.78 | ALDH1A1 (0.54) | ALDH1A1TSHRKMT2AMEN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020216766-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | EVOTEC INTERNATIONAL GMBH (DE) | 2020-10-29 | — | — | WO | disclosed |