Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 3/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 8/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | SMO | Q99835 | 1/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18409588 | 0.89 | DRD4 (0.66) | DRD4TSHRGAAHSD17B10MAPT | |
| SCHEMBL18409487 | 0.88 | DRD4 (0.60) | DRD4GAAMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL22602369 | 0.82 | DRD4 (0.64) | DRD4MAPTMAPK1SMN1; SMN2LMNA | |
| SCHEMBL18409483 | 0.82 | DRD4 (0.50) | DRD4GAAL3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL38662177 | 0.81 | DRD4 (0.52) | DRD4TSHRGAAHSD17B10MAPT | |
| SCHEMBL22602041 | 0.81 | DRD4 (0.53) | DRD4TSHRGAAHSD17B10MAPT | |
| SCHEMBL22602052 | 0.81 | DRD4 (0.50) | DRD4TSHRGAAHSD17B10MAPT | |
| SCHEMBL18409486 | 0.80 | DRD4 (0.49) | DRD4SMN1; SMN2LMNA | |
| SCHEMBL18409504 | 0.79 | ALDH1A1 (0.43) | MAPTL3MBTL1MAPK1SMN1; SMN2SOAT1 | |
| SCHEMBL22602355 | 0.79 | DRD4 (0.50) | DRD4TSHRGAAHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200339554-A1 | COMPOUNDS AND USES THEREOF IN THE TREATMENT OF CANCERS AND OTHER MEDICAL CONDITIONS | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) | 2020-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200339554-A1 | COMPOUNDS AND USES THEREOF IN THE TREATMENT OF CANCERS AND OTHER MEDICAL CONDITIONS | KRAS, NRAS, VHL | DRD4 4249/4885TSHR 4096/4885GAA 690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.