Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 11/20 | 0.59 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.49 |
| ▸ | AHCY | P23526 | 1/20 | 0.47 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22602172 | 1.00 | ATF4 (0.59) | ATF4USP30AHCYANO1GPR119 | |
| SCHEMBL29689471 | 1.00 | ATF4 (0.59) | ATF4USP30AHCYANO1GPR119 | |
| SCHEMBL23702453 | 0.93 | ATF4 (0.64) | ATF4GPR119 | |
| SCHEMBL23702424 | 0.93 | ATF4 (0.64) | ATF4GPR119 | |
| SCHEMBL29689661 | 0.92 | USP30 (0.51) | ATF4USP30AHCYANO1CNR1 | |
| SCHEMBL29689610 | 0.91 | ATF4 (0.55) | ATF4GPR119 | |
| SCHEMBL29690196 | 0.91 | ATF4 (0.55) | ATF4GPR119 | |
| SCHEMBL21389995 | 0.91 | ATF4 (0.59) | ATF4GPR119 | |
| SCHEMBL21384356 | 0.89 | ATF4 (0.68) | ATF4GPR119 | |
| SCHEMBL29619711 | 0.87 | ATF4 (0.65) | ATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020216766-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | EVOTEC INTERNATIONAL GMBH (DE) | 2020-10-29 | — | — | WO | disclosed |