Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 6/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | APP | P05067 | 5/20 | 0.43 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22604724 | 0.96 | PDE4A (0.47) | NPC1RAB9AMEN1CASP3KMT2A | |
| SCHEMBL22588301 | 0.86 | APP (0.49) | NPC1RAB9AMEN1CASP3KMT2A | |
| SCHEMBL22588396 | 0.86 | PDE4A (0.45) | NPC1RAB9AMEN1KMT2APDE4A | |
| SCHEMBL22588415 | 0.82 | PDE4A (0.47) | NPC1RAB9AMEN1KMT2APDE4A | |
| SCHEMBL22588482 | 0.82 | APP (0.48) | NPC1RAB9APDE4APDE4BPDE4C | |
| SCHEMBL22588109 | 0.81 | ALDH1A1 (0.45) | NPC1RAB9AMEN1KMT2APDE4A | |
| SCHEMBL12609109 | 0.78 | MAOB (0.53) | NPC1RAB9AMEN1CASP3KMT2A | |
| SCHEMBL22604627 | 0.77 | BACE1 (0.45) | NPC1RAB9AMEN1KMT2APDE4A | |
| SCHEMBL22588418 | 0.77 | APP (0.48) | NPC1RAB9APDE4APDE4BPDE4C | |
| SCHEMBL22604798 | 0.77 | APP (0.48) | NPC1RAB9APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020216779-A1 | COMPOUNDS COMPRISING N-METHYL-2-PYRIDONE, AND PHARMACEUTICALLY ACCEPTABLE SALTS | UNIVERSITY OF DUNDEE (GB) | 2020-10-29 | — | — | WO | disclosed |