Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21816817 | 0.80 | SMN1; SMN2 (0.39) | SMN1; SMN2GAAALDH1A1NPSR1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL4247948 | 0.78 | SMN1; SMN2 (0.38) | SMN1; SMN2GAAALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL19586771 | 0.77 | ALDH1A1 (0.37) | SMN1; SMN2GAAALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL26130244 | 0.74 | SMN1; SMN2 (0.34) | SMN1; SMN2GAAALDH1A1L3MBTL1 | |
| SCHEMBL19439123 | 0.74 | SMN1; SMN2 (0.34) | SMN1; SMN2GAA | |
| SCHEMBL30613712 | 0.74 | SMN1; SMN2 (0.34) | SMN1; SMN2GAAALDH1A1L3MBTL1 | |
| SCHEMBL17111249 | 0.74 | SMN1; SMN2 (0.34) | SMN1; SMN2GAAALDH1A1L3MBTL1 | |
| SCHEMBL31556868 | 0.72 | GAA (0.41) | SMN1; SMN2GAAALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL19439203 | 0.72 | SMN1; SMN2 (0.30) | SMN1; SMN2 | |
| SCHEMBL17163838 | 0.69 | KDM1A (0.36) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3731869-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2020-11-04 | — | — | EP | disclosed |
| CN-102164909-A | Pyrine or pyrazine derivatives for treating HCV | HOFFMANN LA ROCHE | 2011-08-24 | — | — | CN | disclosed |
| CN-1616386-A | Intermediate for preparing isothiazole derivatives | PFIZER PROD INC (US) | 2005-05-18 | — | — | CN | disclosed |
| CN-1172918-C | Isothiazole derivatives as anticancer agents | �Ʒ� | 2004-10-27 | — | — | CN | disclosed |
| CN-1303380-A | Isothiazole derivatives as anticancer agents | PFIZER PROD INC (US) | 2001-07-11 | — | — | CN | disclosed |