SCHEMBL22609591

SCHEMBL22609591

O=C(O)NCCOCCOCC#Cc1ccc2c3cccnc3n([C@H]3CCC(=O)NC3=O)c2c1

nearest known ligand 0.61

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DDB1 Q16531 20/20 0.61
CRBN Q96SW2 20/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21069275 1.00 DDB1 (0.61) DDB1CRBN
SCHEMBL21071349 0.94 DDB1 (0.67) DDB1CRBN
SCHEMBL22609360 0.94 DDB1 (0.67) DDB1CRBN
SCHEMBL27085660 0.93 DDB1 (0.69) DDB1CRBN
SCHEMBL23807691 0.90 DDB1 (0.76) DDB1CRBN
SCHEMBL29612751 0.90 DDB1 (0.76) DDB1CRBN
SCHEMBL31577894 0.86 DDB1 (0.61) DDB1CRBN
SCHEMBL22609504 0.85 DDB1 (0.55) DDB1CRBN
SCHEMBL21071152 0.85 DDB1 (0.55) DDB1CRBN
SCHEMBL21070751 0.85 DDB1 (0.81) DDB1CRBN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3731869-A1 IRAK DEGRADERS AND USES THEREOF Kymera Therapeutics, Inc. (US) 2020-11-04 EP disclosed