Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 14/20 | 1.00 |
| ▸ | MET | P08581 | 5/20 | 0.76 |
| ▸ | AXL | P30530 | 6/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29755654 | 0.89 | MERTK (1.00) | MERTKMETAXL | |
| SCHEMBL22609727 | 0.89 | MERTK (1.00) | MERTKMETAXL | |
| SCHEMBL22609808 | 0.88 | MERTK (1.00) | MERTKMETAXL | |
| SCHEMBL29755590 | 0.88 | MERTK (1.00) | MERTKMETAXL | |
| SCHEMBL22609945 | 0.86 | MET (1.00) | MERTKMETAXL | |
| SCHEMBL29755563 | 0.86 | MET (1.00) | MERTKMETAXL | |
| SCHEMBL29755664 | 0.84 | MERTK (1.00) | MERTKMETAXL | |
| SCHEMBL22609938 | 0.84 | MERTK (1.00) | MERTKMETAXL | |
| SCHEMBL22609816 | 0.83 | MET (1.00) | MERTKMETAXL | |
| SCHEMBL29755748 | 0.83 | MET (1.00) | MERTKMETAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210009597-A1 | HETEROCYCLE COMPOUNDS AS TYRO3, AXL AND MERTK (TAM) FAMILY OF RECEPTOR TYROSINE KINASE INHIBITORS | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2021-01-14 | — | — | US | claimed |
| EP-3731845-A1 | HETEROCYCLE COMPOUNDS AS TYRO3, AXL AND MERTK (TAM) FAMILY OF RECEPTOR TYROSINE KINASE INHIBITORS | Development Center for Biotechnology (TW) | 2020-11-04 | — | — | EP | claimed |
| US-11407757-B2 | Heterocycle compounds as Tyro3, Axl and MerTK (TAM) family of receptor tyrosine kinase inhibitors | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2022-08-09 | — | — | US | disclosed |
| US-11407757-B2 | Heterocycle compounds as Tyro3, Axl and MerTK (TAM) family of receptor tyrosine kinase inhibitors | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2022-08-09 | — | — | US | disclosed |
| US-20210009597-A1 | HETEROCYCLE COMPOUNDS AS TYRO3, AXL AND MERTK (TAM) FAMILY OF RECEPTOR TYROSINE KINASE INHIBITORS | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2021-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210009597-A1 | HETEROCYCLE COMPOUNDS AS TYRO3, AXL AND MERTK (TAM) FAMILY OF RECEPTOR TYROSINE KINASE INHIBITORS | AXL, TYRO3, MERTK | MERTK 3/4885MET 59/4885AXL 1/4885 |
| US-11407757-B2 | Heterocycle compounds as Tyro3, Axl and MerTK (TAM) family of receptor tyrosine kinase inhibitors | AXL, TYRO3, MERTK | MERTK 3/4885MET 59/4885AXL 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.