Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 20/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.50 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.50 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20600025 | 0.97 | GRM5 (0.68) | GRM5CYP1A2CYP3A4CACNA1CSCN5A | |
| SCHEMBL20600026 | 0.97 | GRM5 (0.68) | GRM5CYP1A2CYP3A4CACNA1CSCN5A | |
| SCHEMBL20600042 | 0.94 | GRM5 (0.67) | GRM5CYP1A2CYP3A4CACNA1CSCN5A | |
| SCHEMBL20600043 | 0.94 | GRM5 (0.67) | GRM5CYP1A2CYP3A4CACNA1CSCN5A | |
| SCHEMBL20600053 | 0.84 | GRM5 (0.58) | GRM5CYP1A2CYP3A4CACNA1CSCN5A | |
| SCHEMBL20600055 | 0.84 | GRM5 (0.58) | GRM5CYP1A2CYP3A4CACNA1CSCN5A | |
| SCHEMBL3639566 | 0.79 | GRM5 (1.00) | GRM5CYP1A2CYP3A4CACNA1CSCN5A | |
| SCHEMBL29915293 | 0.78 | GRM5 (0.40) | GRM5 | |
| SCHEMBL22619510 | 0.77 | GRM5 (0.78) | GRM5CYP1A2CYP3A4CACNA1CSCN5A | |
| SCHEMBL29915426 | 0.77 | GRM5 (0.78) | GRM5CYP1A2CYP3A4CACNA1CSCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200347078-A1 | HETEROCYCLYLMETHYLIDENE DERIVATIVES AND THEIR USE AS MODULATORS OF mGluR5 RECEPTORS | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.P.A. (IT) | 2020-11-05 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200347078-A1 | HETEROCYCLYLMETHYLIDENE DERIVATIVES AND THEIR USE AS MODULATORS OF mGluR5 RECEPTORS | GRM5, GRIK5, GRM2 | GRM5 1/4885CYP1A2 3556/4885CYP3A4 4025/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.