Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.32 |
| ▸ | SPR | P35270 | 2/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22613609 | 0.83 | — | — | |
| SCHEMBL20600025 | 0.80 | GRM5 (0.68) | GRM5 | |
| SCHEMBL20600026 | 0.80 | GRM5 (0.68) | GRM5 | |
| SCHEMBL22613682 | 0.78 | GRM5 (0.64) | GRM5 | |
| SCHEMBL513283 | 0.77 | GRM5 (0.61) | GRM5 | |
| SCHEMBL31637254 | 0.76 | GRM5 (0.34) | GRM5JAK3GRIN2BGRIN2C | |
| SCHEMBL29915467 | 0.75 | GRM5 (0.47) | GRM5UCHL1 | |
| SCHEMBL3639663 | 0.75 | GRM5 (0.53) | GRM5 | |
| SCHEMBL3639664 | 0.75 | GRM5 (0.53) | GRM5 | |
| SCHEMBL4485043 | 0.74 | GRIN2B (0.39) | JAK3SPRGRIN2BGRIN2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11440922-B2 | Heterocyclylmethylidene derivatives and their use as modulators of mGluR5 receptors | Recordati Industria Chimica e Farmacentica S.p.A. (IT) | 2022-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11440922-B2 | Heterocyclylmethylidene derivatives and their use as modulators of mGluR5 receptors | GRM5, GRIK5, GRM2 | GRM5 1/4885JAK3 3288/4885UCHL1 2775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.