Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.77 |
| ▸ | APEX1 | P27695 | 1/20 | 0.77 |
| ▸ | RECQL | P46063 | 1/20 | 0.77 |
| ▸ | MAPT | P10636 | 3/20 | 0.73 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.63 |
| ▸ | HPGD | P15428 | 6/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | GFER | P55789 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1286369 | 0.86 | POLB (0.79) | POLBAPEX1RECQLMAPTALOX5 | |
| SCHEMBL8984918 | 0.85 | POLB (0.76) | POLBAPEX1RECQLMAPTALOX5 | |
| SCHEMBL5401249 | 0.84 | POLB (0.77) | POLBAPEX1RECQLMAPTALOX5 | |
| SCHEMBL13629728 | 0.84 | MAPT (1.00) | POLBAPEX1RECQLMAPTALOX5 | |
| SCHEMBL9375886 | 0.84 | POLB (0.71) | POLBAPEX1RECQLMAPTALOX5 | |
| SCHEMBL10759553 | 0.83 | POLB (0.75) | POLBAPEX1RECQLMAPTALOX5 | |
| SCHEMBL10404196 | 0.82 | POLB (0.73) | POLBAPEX1RECQLMAPTALOX5 | |
| SCHEMBL10404194 | 0.82 | POLB (0.73) | POLBAPEX1RECQLMAPTALOX5 | |
| SCHEMBL13461102 | 0.82 | POLB (0.83) | POLBAPEX1RECQLMAPTALOX5 | |
| SCHEMBL10404170 | 0.81 | POLB (0.71) | POLBAPEX1RECQLMAPTALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110195500-A1 | METHODS AND COMPOSITIONS FOR MITIGATING EOSINOPHILIC ESOPHAGITIS BY MODULATING LEVELS AND ACTIVITY OF EOTAXIN-3 | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2011-08-11 | — | — | US | claimed |
| US-20090233275-A1 | EOTAXIN-3 IN EOSINOPHILIC ESOPHAGITIS | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2009-09-17 | — | — | US | claimed |
| WO-2006083390-A2 | EOTAXIN-3 IN EOSINOPHILIC ESOPHAGITIS | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2006-08-10 | — | — | WO | claimed |
| US-10155985-B2 | Evaluation of eosinophilic esophagitis | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2018-12-18 | — | — | US | disclosed |
| US-20170067111-A1 | Evaluation of Eosinophilic Esophagitis | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2017-03-09 | — | — | US | disclosed |
| US-8030003-B2 | Diagnosis of eosinophilic esophagitis based on presence of an elevated level of eotaxin-3 | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2011-10-04 | — | — | US | disclosed |
| US-20110195500-A1 | METHODS AND COMPOSITIONS FOR MITIGATING EOSINOPHILIC ESOPHAGITIS BY MODULATING LEVELS AND ACTIVITY OF EOTAXIN-3 | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2011-08-11 | — | — | US | disclosed |
| US-20090269774-A1 | EVALUATION OF EOSINOPHILIC ESOPHAGITIS | CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2009-10-29 | — | — | US | disclosed |
| US-20090233275-A1 | EOTAXIN-3 IN EOSINOPHILIC ESOPHAGITIS | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2009-09-17 | — | — | US | disclosed |
| CN-101437795-A | Piperidine derivatives, process for their preparation, their use as therapeutic agents and pharmaceutical compositions containing them | ASTRAZENECA AB (SE) | 2009-05-20 | — | — | CN | disclosed |
| US-20090023733-A1 | Piperidine Derivatives, Their Process for Preparation, Their Use as Therapeutic Agents and Pharmaceutical Compositions Containing Them | ASTRAZENECA AB (SE) | 2009-01-22 | — | — | US | disclosed |
| EP-1363925-B1 | MACROLIDE ANTIBIOTICS | GLAXO GROUP LTD (GB) | 2006-11-15 | — | — | EP | disclosed |
| US-20060211636-A1 | Macrolide Antibiotics | ALIHODZIC SULEJMAN | 2006-09-21 | — | — | US | disclosed |
| WO-2006083390-A2 | EOTAXIN-3 IN EOSINOPHILIC ESOPHAGITIS | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2006-08-10 | — | — | WO | disclosed |
| US-20050215495-A1 | Macrolide antibiotics | ALIHODZIC SULEJMAN | 2005-09-29 | — | — | US | disclosed |
| US-20040077557-A1 | Macrolide antibiotics | GLAXO GROUP LIMITED (GB) | 2004-04-22 | — | — | US | disclosed |
| US-4719036-A | PAINTS; METAL WORKING | CIBA-GEIGY CORPORATION (US) | 1988-01-12 | — | — | US | disclosed |
| US-4329363-A | Substituted mercapto acid amides and their use | MERCK & CO., INC. (US) | 1982-05-11 | — | — | US | disclosed |
| EP-0006347-A1 | Compositions and method for regulating soybean plant growth utilizing substituted benzazolylthioalkanoic acids | MONSANTO COMPANY (US) | 1980-01-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050215495-A1 | Macrolide antibiotics | IL1R1, MRPL12, RPS21 | POLB 2625/4885APEX1 4284/4885RECQL 1088/4885 |
| US-20090023733-A1 | Piperidine Derivatives, Their Process for Preparation, Their Use as Therapeutic Agents and Pharmaceutical Compositions Containing Them | CCR3, CCR1, CCR5 | POLB 1667/4885APEX1 3375/4885RECQL 4059/4885 |
| US-20060211636-A1 | Macrolide Antibiotics | IL1R1, MRPL12, RPS21 | POLB 2625/4885APEX1 4284/4885RECQL 1088/4885 |
| US-20040077557-A1 | Macrolide antibiotics | MALT1, MRPL21, IL1R1 | POLB 2847/4885APEX1 3848/4885RECQL 1269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.