Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.52 |
| ▸ | JAK1 | P23458 | 3/20 | 0.52 |
| ▸ | TYK2 | P29597 | 3/20 | 0.52 |
| ▸ | JAK3 | P52333 | 3/20 | 0.52 |
| ▸ | CDK1 | P06493 | 2/20 | 0.51 |
| ▸ | CDK4 | P11802 | 2/20 | 0.51 |
| ▸ | CCND1 | P24385 | 2/20 | 0.51 |
| ▸ | CDK2 | P24941 | 2/20 | 0.51 |
| ▸ | JUN | P05412 | 2/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 10/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 10/20 | 0.46 |
| ▸ | MERTK | Q12866 | 10/20 | 0.46 |
| ▸ | GAS6 | Q14393 | 10/20 | 0.46 |
| ▸ | AXL | P30530 | 3/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL558814 | 1.00 | JAK2 (0.52) | JAK2JAK1TYK2JAK3CDK1 | |
| SCHEMBL2256391 | 0.91 | JUN (0.48) | JAK2JAK1TYK2JAK3CDK1 | |
| SCHEMBL559378 | 0.91 | JUN (0.48) | JAK2JAK1TYK2JAK3CDK1 | |
| SCHEMBL2256528 | 0.90 | MAPK10 (0.56) | JUNMAPK10MAPK8FLT3TYRO3 | |
| SCHEMBL2256524 | 0.90 | MAPK10 (0.56) | JUNMAPK10MAPK8FLT3TYRO3 | |
| SCHEMBL559200 | 0.87 | FLT3 (0.60) | JAK2JAK1TYK2JAK3CDK1 | |
| SCHEMBL2255229 | 0.87 | FLT3 (0.60) | JAK2JAK1TYK2JAK3CDK1 | |
| SCHEMBL2261007 | 0.87 | MAPK10 (0.53) | JUNMAPK10MAPK8FLT3TYRO3 | |
| SCHEMBL558808 | 0.87 | MAPK10 (0.53) | JUNMAPK10MAPK8FLT3TYRO3 | |
| SCHEMBL10166789 | 0.86 | JUN (0.46) | JAK2JAK1TYK2JAK3CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998978-B2 | Substituted 2-amino-fused heterocyclic compounds | PFIZER INC. (US) | 2011-08-16 | — | — | US | disclosed |
| US-20100056506-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056506-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | MAPK1, SLC5A1, ATF1 | JAK2 54/4885JAK1 87/4885TYK2 1929/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.