Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.31 |
| ▸ | FEN1 | P39748 | 2/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2112213 | 0.86 | DGAT1 (0.43) | DGAT1NPC1BRD4CREBBPMAPT | |
| SCHEMBL21632526 | 0.85 | DGAT1 (0.42) | DGAT1NPC1BRD4CREBBPMAPT | |
| SCHEMBL1565433 | 0.85 | DGAT1 (0.40) | DGAT1NPC1BRD4CREBBPMAPT | |
| SCHEMBL2115664 | 0.85 | DGAT1 (0.40) | DGAT1NPC1BRD4CREBBPMAPT | |
| SCHEMBL21858990 | 0.84 | DGAT1 (0.39) | DGAT1BRD4CREBBPMAPT | |
| SCHEMBL2112413 | 0.84 | DGAT1 (0.39) | DGAT1BRD4CREBBP | |
| SCHEMBL10099308 | 0.82 | DGAT1 (0.34) | DGAT1NPC1BRD4CREBBPMAPT | |
| SCHEMBL566964 | 0.82 | KDM4E (0.34) | DGAT1NPC1MAPT | |
| SCHEMBL21958346 | 0.81 | DGAT1 (0.38) | DGAT1MAPT | |
| SCHEMBL101528 | 0.81 | DGAT1 (0.40) | DGAT1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020223728-A1 | SUBSTITUTED PYRROLOPYRIDINES AS JAK INHIBITORS | ACLARIS THERAPEUTICS, INC. (US) | 2020-11-05 | — | — | WO | disclosed |