Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12814322 | 0.87 | CTSK (0.54) | CTSKBTKCA1CA2HSD11B1 | |
| SCHEMBL24087331 | 0.84 | CTSK (0.47) | CTSKBTKCA1CA2HSD11B1 | |
| SCHEMBL24076246 | 0.84 | CTSK (0.47) | CTSKBTKCA1CA2HSD11B1 | |
| SCHEMBL30054708 | 0.83 | CTSK (0.46) | CTSKBTKCA1CA2HSD11B1 | |
| SCHEMBL25085897 | 0.83 | CTSK (0.46) | CTSKBTKCA1CA2HSD11B1 | |
| SCHEMBL17859548 | 0.83 | CTSK (0.46) | CTSKBTKCA1CA2HSD11B1 | |
| SCHEMBL17859549 | 0.83 | CTSK (0.46) | CTSKBTKCA1CA2HSD11B1 | |
| SCHEMBL16665756 | 0.83 | CTSK (0.46) | CTSKBTKCA1CA2HSD11B1 | |
| SCHEMBL24087333 | 0.82 | CTSK (0.45) | CTSKBTKCA1CA2HSD11B1 | |
| SCHEMBL20498700 | 0.82 | BTK (0.48) | CTSKBTKCA1CA2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020223728-A1 | SUBSTITUTED PYRROLOPYRIDINES AS JAK INHIBITORS | ACLARIS THERAPEUTICS, INC. (US) | 2020-11-05 | — | — | WO | disclosed |