⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22625609 | 0.85 | KRAS (0.31) | — | |
| SCHEMBL22612825 | 0.73 | ULK1 (0.34) | — | |
| SCHEMBL29699267 | 0.61 | RAF1 (0.38) | — | |
| SCHEMBL22612761 | 0.58 | RAF1 (0.34) | — | |
| SCHEMBL22612769 | 0.58 | FGFR1 (0.32) | — | |
| SCHEMBL31390052 | 0.54 | SMN1; SMN2 (0.40) | — | |
| SCHEMBL31344333 | 0.52 | HASPIN (0.36) | — | |
| SCHEMBL22625552 | 0.51 | SMN1; SMN2 (0.33) | — | |
| SCHEMBL21416833 | 0.50 | KRAS (0.34) | — | |
| SCHEMBL16683500 | 0.48 | MEN1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11667634-B2 | Inhibitors of RAF kinases | KINNATE BIOPHARMA INC. (US) | 2023-06-06 | — | — | US | disclosed |
| US-20210246135-A1 | INHIBITORS OF RAF KINASES | Pierre Fabre Médicament (FR) | 2021-08-12 | — | — | US | disclosed |
| US-10927111-B2 | Inhibitors of RAF kinases | KINNATE BIOPHARMA INC. (US) | 2021-02-23 | — | — | US | disclosed |
| US-20200347052-A1 | INHIBITORS OF RAF KINASES | Pierre Fabre Médicament (FR) | 2020-11-05 | — | — | US | disclosed |