SCHEMBL22625713

SCHEMBL22625713

CON1Cc2c(N)cccc2C1=O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 1/20 0.44
TNF P01375 1/20 0.44
IL1B P01584 1/20 0.44
IKZF1 Q13422 1/20 0.44
DDB1 Q16531 1/20 0.44
CRBN Q96SW2 1/20 0.44
IKZF3 Q9UKT9 1/20 0.44
UGCG Q16739 2/20 0.41
PARP1 P09874 1/20 0.39
DPP4 P27487 1/20 0.37
ADORA2A P29274 2/20 0.36
ATM Q13315 3/20 0.36
MEN1 O00255 3/20 0.36
KMT2A Q03164 3/20 0.36
NPC1 O15118 3/20 0.36
RAB9A P51151 3/20 0.36
KDM4E B2RXH2 2/20 0.36
ALDH1A1 P00352 1/20 0.36
POLB P06746 1/20 0.36
MAPT P10636 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20645748 0.80 UGCG (0.51) UGCGMEN1KMT2AKDM4EHTR2B
SCHEMBL5906568 0.77 BRD4 (0.47) BRD4TNFIL1BIKZF1DDB1
SCHEMBL14353179 0.75 HDAC4 (0.44) UGCGNPC1RAB9AKDM4EMAPT
SCHEMBL14352147 0.75 DHPS (0.40) UGCGKDM4EALDH1A1HPGDSMN1; SMN2
SCHEMBL24637348 0.75 BRD4 (0.36) BRD4TNFIL1BIKZF1DDB1
SCHEMBL9934256 0.74 IDH1 (0.48) BRD4TNFIL1BIKZF1DDB1
SCHEMBL19934031 0.74 TNF (0.50) BRD4TNFIL1BIKZF1DDB1
SCHEMBL15784143 0.73 TNF (0.44) BRD4TNFIL1BIKZF1DDB1
SCHEMBL7952458 0.73 IDH1 (0.46) BRD4TNFIL1BIKZF1DDB1
SCHEMBL1949749 0.73 BRD4 (0.44) BRD4TNFIL1BIKZF1DDB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11203585-B2 Crystalline forms of lenalidomide BIOCON LIMITED (IN) 2021-12-21 US disclosed
US-20200347027-A1 CRYSTALLINE FORMS OF LENALIDOMIDE BIOCON LIMITED (IN) 2020-11-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200347027-A1 CRYSTALLINE FORMS OF LENALIDOMIDE CRBN, SALL4, RDX BRD4 187/4885TNF 687/4885IL1B 876/4885
US-11203585-B2 Crystalline forms of lenalidomide CRBN, SALL4, RDX BRD4 187/4885TNF 687/4885IL1B 876/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.