Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 11/20 | 0.70 |
| ▸ | BCR | P11274 | 9/20 | 0.70 |
| ▸ | PRKCA | P17252 | 6/20 | 0.66 |
| ▸ | KIT | P10721 | 4/20 | 0.63 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.61 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.61 |
| ▸ | EGFR | P00533 | 6/20 | 0.60 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.60 |
| ▸ | JAK3 | P52333 | 1/20 | 0.57 |
| ▸ | BTK | Q06187 | 1/20 | 0.57 |
| ▸ | ITK | Q08881 | 1/20 | 0.57 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | PRKACA | P17612 | 1/20 | 0.56 |
| ▸ | PRKACG | P22612 | 1/20 | 0.56 |
| ▸ | PRKACB | P22694 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | PRKCG | P05129 | 1/20 | 0.56 |
| ▸ | PRKCB | P05771 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | PRKCH | P24723 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12320924 | 0.90 | ABL1 (0.78) | ABL1BCRPRKCAKITPDGFRB | |
| SCHEMBL3860532 | 0.88 | ABL1 (0.83) | ABL1BCRPRKCAKITPDGFRB | |
| SCHEMBL27776936 | 0.87 | ABL1 (0.65) | ABL1BCRPRKCAKITPDGFRB | |
| SCHEMBL21004291 | 0.87 | ABL1 (0.64) | ABL1BCRPRKCAKITPDGFRB | |
| SCHEMBL19575436 | 0.86 | ABL1 (0.62) | ABL1BCRPRKCAKITPDGFRB | |
| SCHEMBL21004289 | 0.86 | ABL1 (0.62) | ABL1BCRPRKCAKITPDGFRB | |
| SCHEMBL4373707 | 0.86 | ABL1 (0.72) | ABL1BCRPRKCAKITPDGFRB | |
| SCHEMBL7472267 | 0.84 | PIK3CG (0.57) | ABL1BCRPRKCAKITPDGFRB | |
| SCHEMBL17782807 | 0.84 | ABL1 (0.77) | ABL1BCRPRKCAKITPDGFRB | |
| SCHEMBL3861941 | 0.84 | ABL1 (0.69) | ABL1BCRPRKCAKITPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452465-B1 | SUBSTITUTED 2, 4-DIAMINO-QUINOLINE DERIVATIVES FOR USE IN THE TREATMENT OF PROLIFERATIVE DISEASES | GENOSCIENCE PHARMA (FR) | 2020-11-04 | — | — | EP | disclosed |