SCHEMBL22635976

SCHEMBL22635976

O=P(O)(O)OP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(O)ncnc32)[C@H](O)[C@@H]1O.[NaH].[NaH]

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RX3 P56373 7/20 0.72
P2RY1 P47900 6/20 0.72
P2RX2 Q9UBL9 6/20 0.72
P2RY2 P41231 3/20 0.72
P2RX1 P51575 3/20 0.72
P2RX4 Q99571 2/20 0.72
SRC P12931 2/20 0.72
SMN1; SMN2 Q16637 2/20 0.72
ALDH1A1 P00352 2/20 0.72
RNASEL Q05823 1/20 0.72
TRPM2 O94759 2/20 0.68
MACROD2 A1Z1Q3 1/20 0.68
SIRT6 Q8N6T7 1/20 0.68
MACROD1 Q9BQ69 1/20 0.68
GPR17 Q13304 1/20 0.67
DNPH1 O43598 1/20 0.66
PRKAB2 O43741 1/20 0.66
LDHA P00338 1/20 0.66
ADRB2 P07550 1/20 0.66
FBP1 P09467 1/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28009685 0.99 P2RY1 (0.74) P2RX3P2RY1P2RX2P2RY2P2RX1
SCHEMBL27837591 0.99 P2RY1 (0.74) P2RX3P2RY1P2RX2P2RY2P2RX1
SCHEMBL29134096 0.99 P2RY1 (0.74) P2RX3P2RY1P2RX2P2RY2P2RX1
SCHEMBL23711717 0.99 P2RX3 (0.74) P2RX3P2RY1P2RX2P2RY2P2RX1
SCHEMBL30112894 0.99 P2RX3 (0.74) P2RX3P2RY1P2RX2P2RY2P2RX1
SCHEMBL162915 0.99 P2RX3 (0.74) P2RX3P2RY1P2RX2P2RY2P2RX1
SCHEMBL162914 0.99 P2RX3 (0.74) P2RX3P2RY1P2RX2P2RY2P2RX1
SCHEMBL1331745 0.98 P2RY1 (0.75) P2RX3P2RY1P2RX2P2RY2P2RX1
SCHEMBL1331755 0.98 P2RY1 (0.75) P2RX3P2RY1P2RX2P2RY2P2RX1
SCHEMBL163281 0.98 P2RY1 (0.75) P2RX3P2RY1P2RX2P2RY2P2RX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12533371-B2 Multilayer pharmaceutical or nutraceutical solid dosage forms comprising pyrimidine and/or purine derivatives and b vitamins, preparation and uses thereof FERRER INTERNACIONAL, S.A. (ES) 2026-01-27 US disclosed
CN-113784706-B Multi-layered pharmaceutical or nutraceutical solid dosage forms comprising pyrimidine and/or purine derivatives and B vitamins, their preparation and use 菲尔若国际公司 2024-01-05 CN disclosed
US-20220160744-A1 MULTILAYER PHARMACEUTICAL OR NUTRACEUTICAL SOLID DOSAGE FORMS COMPRISING PYRIMIDINE AND/OR PURINE DERIVATIVES AND B VITAMINS, PREPARATION AND USES THEREOF FERRER INTERNACIONAL, S.A. (ES) 2022-05-26 US disclosed
EP-3965744-A1 MULTILAYER PHARMACEUTICAL OR NUTRACEUTICAL SOLID DOSAGE FORMS COMPRISING PYRIMIDINE AND/OR PURINE DERIVATIVES AND B VITAMINS, PREPARATION AND USES THEREOF Ferrer Internacional, S.A. (ES) 2022-03-16 EP disclosed
CN-113784706-A Multi-layered pharmaceutical or nutraceutical solid dosage form comprising pyrimidine and/or purine derivatives and B vitamins, preparation and use thereof 菲尔若国际公司 2021-12-10 CN disclosed
WO-2020224795-A1 MULTILAYER PHARMACEUTICAL OR NUTRACEUTICAL SOLID DOSAGE FORMS COMPRISING PYRIMIDINE AND/OR PURINE DERIVATIVES AND B VITAMINS, PREPARATION AND USES THEREOF FERRER INTERNACIONAL, S.A. (ES) 2020-11-12 WO disclosed
CN-103254260-B The method of symmetric double nucleoside diphosphate disodium salt is synthesized by nucleosides hydrogen monophosphite JIANGXI SCIENCE & TECHNOLOGY NORMAL UNIVERSITY (CN) 2015-11-11 CN disclosed
CN-103254260-A Method for synthesizing symmetric dinucleoside diphosphate disodium salt from nucleoside hydrogen phosphite monoester UNIV JIANGXI NORMAL SCI & TECH 2013-08-21 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12533371-B2 Multilayer pharmaceutical or nutraceutical solid dosage forms comprising pyrimidine and/or purine derivatives and b vitamins, preparation and uses thereof P2RY10, TYMP, P2RY12 P2RX3 21/4885P2RY1 14/4885P2RX2 48/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.