Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | KCNT1 | Q5JUK3 | 5/20 | 0.52 |
| ▸ | PPARD | Q03181 | 6/20 | 0.50 |
| ▸ | PPARA | Q07869 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ACACB | O00763 | 5/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22637673 | 0.87 | TDP1 (0.54) | TDP1TP53SMN1; SMN2KCNT1PPARD | |
| SCHEMBL22637723 | 0.85 | KCNT1 (0.64) | TDP1TP53SMN1; SMN2KCNT1PPARD | |
| SCHEMBL22637724 | 0.85 | KCNT1 (0.64) | TDP1TP53SMN1; SMN2KCNT1PPARD | |
| SCHEMBL22637840 | 0.85 | KCNT1 (0.64) | TDP1TP53SMN1; SMN2KCNT1PPARD | |
| SCHEMBL24660606 | 0.85 | TDP1 (0.50) | TDP1TP53SMN1; SMN2KCNT1PPARD | |
| SCHEMBL29463534 | 0.85 | TDP1 (0.50) | TDP1TP53SMN1; SMN2KCNT1PPARD | |
| SCHEMBL22637923 | 0.84 | TDP1 (0.56) | TDP1TP53SMN1; SMN2KCNT1PPARD | |
| SCHEMBL22637761 | 0.83 | TDP1 (0.55) | TDP1TP53SMN1; SMN2KCNT1PPARD | |
| SCHEMBL22637893 | 0.83 | KCNT1 (0.64) | TDP1TP53SMN1; SMN2KCNT1PPARD | |
| SCHEMBL22637891 | 0.83 | KCNT1 (0.64) | TDP1TP53SMN1; SMN2KCNT1PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3962481-A1 | KCNT1 INHIBITORS AND METHODS OF USE | Praxis Precision Medicines, Inc. (US) | 2022-03-09 | — | — | EP | disclosed |
| WO-2020227101-A1 | KCNT1 INHIBITORS AND METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. (US) | 2020-11-12 | — | — | WO | disclosed |