Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNT1 | Q5JUK3 | 6/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | ACACB | O00763 | 5/20 | 0.53 |
| ▸ | PPARD | Q03181 | 2/20 | 0.53 |
| ▸ | PPARA | Q07869 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | IDH1 | O75874 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22637724 | 1.00 | KCNT1 (0.64) | KCNT1TDP1TP53SMN1; SMN2ACACB | |
| SCHEMBL22637723 | 1.00 | KCNT1 (0.64) | KCNT1TDP1TP53SMN1; SMN2ACACB | |
| SCHEMBL22637923 | 0.89 | TDP1 (0.56) | KCNT1TDP1TP53SMN1; SMN2ACACB | |
| SCHEMBL22637893 | 0.88 | KCNT1 (0.64) | KCNT1TDP1TP53SMN1; SMN2ACACB | |
| SCHEMBL22637761 | 0.88 | TDP1 (0.55) | KCNT1TDP1TP53SMN1; SMN2ACACB | |
| SCHEMBL22637891 | 0.88 | KCNT1 (0.64) | KCNT1TDP1TP53SMN1; SMN2ACACB | |
| SCHEMBL22637834 | 0.85 | TDP1 (0.58) | KCNT1TDP1TP53SMN1; SMN2ACACB | |
| SCHEMBL22637849 | 0.85 | S1PR3 (0.60) | KCNT1TDP1TP53SMN1; SMN2ACACB | |
| SCHEMBL22637851 | 0.85 | S1PR3 (0.60) | KCNT1TDP1TP53SMN1; SMN2ACACB | |
| SCHEMBL3115663 | 0.85 | KCNT1 (0.60) | KCNT1TDP1TP53SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3962481-A1 | KCNT1 INHIBITORS AND METHODS OF USE | Praxis Precision Medicines, Inc. (US) | 2022-03-09 | — | — | EP | disclosed |
| WO-2020227101-A1 | KCNT1 INHIBITORS AND METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. (US) | 2020-11-12 | — | — | WO | disclosed |