Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22639025 | 0.84 | TP53 (0.41) | KDM4EALDH1A1IKBKBCHUKLIMK1 | |
| SCHEMBL1697886 | 0.80 | HDAC3 (0.32) | KDM4EALDH1A1KMT2APOLBHPGD | |
| SCHEMBL29199696 | 0.80 | IKBKB (0.46) | KDM4EALDH1A1IKBKBLIMK1KMT2A | |
| SCHEMBL843920 | 0.73 | KDM4E (0.56) | KDM4EALDH1A1IKBKBCHUKLIMK1 | |
| SCHEMBL9539962 | 0.71 | KDM4E (0.57) | KDM4EALDH1A1IKBKBCHUKLIMK1 | |
| SCHEMBL10405198 | 0.71 | KDM4E (0.57) | KDM4EALDH1A1IKBKBCHUKLIMK1 | |
| SCHEMBL3836628 | 0.70 | LIMK1 (0.77) | KDM4EALDH1A1IKBKBCHUKLIMK1 | |
| SCHEMBL3493221 | 0.70 | KDM4E (0.56) | KDM4EALDH1A1IKBKBCHUKLIMK1 | |
| SCHEMBL15417422 | 0.70 | KDM4E (0.56) | KDM4EALDH1A1IKBKBCHUKLIMK1 | |
| SCHEMBL15931649 | 0.70 | KDM4E (0.56) | KDM4EALDH1A1IKBKBCHUKLIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220213118-A1 | UBIQUITIN-SPECIFIC PROTEASE INHIBITOR AND PREPARATION METHOD THEREFOR AND USE THEREOFF | CHASER THERAPEUTICS, INC. (CN) | 2022-07-07 | — | — | US | disclosed |
| EP-3954694-A1 | UBIQUITIN-SPECIFIC PROTEASE INHIBITORS, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Chaser Therapeutics, Inc. (CN) | 2022-02-16 | — | — | EP | disclosed |
| WO-2020224652-A1 | UBIQUITIN-SPECIFIC PROTEASE INHIBITORS, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 北京普济远成生物科技有限公司 | 2020-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220213118-A1 | UBIQUITIN-SPECIFIC PROTEASE INHIBITOR AND PREPARATION METHOD THEREFOR AND USE THEREOFF | USP28, USP25, USP24 | KDM4E 2500/4885ALDH1A1 1156/4885IKBKB 489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.