Sugi Predict

Sugi Predict / Compounds / SCHEMBL22639152

SCHEMBL22639152

SCHEMBL22639152

Nc1ccc2c(c1)CN(C1CCCC(=O)NC1=O)C2=O

nearest known ligand 0.86

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 12/20 0.86
▸ IKZF2 Q9UKS7 8/20 0.57
▸ DDB1 Q16531 2/20 0.54
▸ CSNK1A1 P48729 1/20 0.52
▸ BRD4 O60885 1/20 0.51
▸ TNF P01375 1/20 0.51
▸ IL1B P01584 1/20 0.51
▸ IKZF1 Q13422 1/20 0.51
▸ IKZF3 Q9UKT9 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18270982 1.00 CRBN (0.86) CRBNIKZF2DDB1CSNK1A1BRD4
SCHEMBL29440001 0.93 CRBN (1.00) CRBNIKZF2DDB1CSNK1A1BRD4
SCHEMBL501751 0.93 CRBN (1.00) CRBNIKZF2DDB1CSNK1A1BRD4
SCHEMBL20234431 0.93 CRBN (1.00) CRBNIKZF2DDB1CSNK1A1BRD4
SCHEMBL30930592 0.85 CRBN (0.63) CRBNIKZF2DDB1CSNK1A1
SCHEMBL18270971 0.85 CRBN (0.63) CRBNIKZF2CSNK1A1
SCHEMBL19611952 0.85 CRBN (0.63) CRBNIKZF2DDB1IKZF3
SCHEMBL19611954 0.85 CRBN (0.63) CRBNIKZF2DDB1IKZF3
SCHEMBL20231070 0.83 CRBN (0.82) CRBNIKZF2DDB1CSNK1A1BRD4
SCHEMBL30405557 0.82 CRBN (0.66) CRBNIKZF2DDB1CSNK1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10828643-B2 Oligonucleotide encoded chemical libraries Plexium, Inc. (US) 2020-11-10 — — US disclosed