SCHEMBL30930592

SCHEMBL30930592

O=C1CCCC(N2Cc3cc(Br)ccc3C2=O)C(=O)N1

nearest known ligand 0.63

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 11/20 0.63
IKZF2 Q9UKS7 9/20 0.54
DDB1 Q16531 1/20 0.54
CSNK1A1 P48729 3/20 0.52
SALL4 Q9UJQ4 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31726960 0.93 CRBN (0.73) CRBNIKZF2DDB1CSNK1A1SALL4
SCHEMBL27305814 0.93 CRBN (0.73) CRBNIKZF2DDB1CSNK1A1SALL4
SCHEMBL4449425 0.93 CRBN (0.73) CRBNIKZF2DDB1CSNK1A1SALL4
SCHEMBL29614623 0.93 CRBN (0.73) CRBNIKZF2DDB1CSNK1A1SALL4
SCHEMBL22639152 0.85 CRBN (0.86) CRBNIKZF2DDB1CSNK1A1
SCHEMBL18270982 0.85 CRBN (0.86) CRBNIKZF2DDB1CSNK1A1
SCHEMBL18270971 0.85 CRBN (0.63) CRBNIKZF2CSNK1A1
SCHEMBL19100445 0.83 CRBN (0.61) CRBNIKZF2DDB1CSNK1A1SALL4
SCHEMBL30984806 0.83 CRBN (0.67) CRBNIKZF2DDB1CSNK1A1SALL4
SCHEMBL19792875 0.83 CRBN (0.57) CRBNIKZF2DDB1CSNK1A1SALL4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4612140-A1 NEK7 DEGRADERS AND METHODS OF USE THEREOF Captor Therapeutics S.A. (PL) 2025-09-10 EP disclosed
WO-2024094819-A1 NEK7 DEGRADERS AND METHODS OF USE THEREOF CAPTOR THERAPEUTICS S.A. (PL) 2024-05-10 WO disclosed