SCHEMBL22639693

SCHEMBL22639693

c1ccc([Si](c2ccccc2)(c2ccccc2)c2ccc(C3(c4cccc5c4oc4ccccc45)c4ccccc4-c4ccccc43)cc2)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 3/20 0.38
MEN1 O00255 4/20 0.36
KMT2A Q03164 4/20 0.36
MAPT P10636 3/20 0.36
LMNA P02545 3/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
KDM4E B2RXH2 1/20 0.36
OPRK1 P41145 1/20 0.36
PRKDC P78527 4/20 0.33
PIK3CD O00329 1/20 0.33
PIK3CB P42338 1/20 0.33
NPC1 O15118 2/20 0.32
RAB9A P51151 2/20 0.32
CYP2C19 P33261 1/20 0.32
ALDH1A1 P00352 1/20 0.32
HPGD P15428 1/20 0.32
ESR1 P03372 1/20 0.32
ESR2 Q92731 1/20 0.32
CDK2 P24941 1/20 0.31
CSF1R P07333 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL440074 0.89 ALOX5 (0.43) ALOX5MEN1KMT2AMAPTLMNA
SCHEMBL22639850 0.86 MEN1 (0.33) ALOX5MEN1KMT2AMAPTLMNA
SCHEMBL437591 0.83 ALOX5 (0.50) ALOX5MEN1KMT2AMAPTLMNA
SCHEMBL23597946 0.83 ALOX5 (0.39) ALOX5MEN1KMT2AMAPTLMNA
SCHEMBL438617 0.82 ALOX5 (0.49) ALOX5MEN1KMT2AMAPTLMNA
SCHEMBL16631106 0.82 ALOX5 (0.38) ALOX5MEN1KMT2AMAPTLMNA
SCHEMBL16631108 0.82 KDM4E (0.39) ALOX5MEN1KMT2AMAPTLMNA
SCHEMBL22639848 0.80 ALOX5 (0.36) ALOX5MEN1KMT2AMAPTLMNA
SCHEMBL16838908 0.79 ALOX5 (0.40) ALOX5MEN1KMT2AMAPTLMNA
SCHEMBL17774323 0.79 ALOX5 (0.40) ALOX5MEN1KMT2AMAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10833280-B2 Condensed cyclic compound and organic light-emitting device including the same SAMSUNG DISPLAY CO., LTD. (KR) 2020-11-10 US disclosed