Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 13/20 | 0.48 |
| ▸ | ERN1 | O75460 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 2/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.45 |
| ▸ | CDK2 | P24941 | 3/20 | 0.45 |
| ▸ | FPR2 | P25090 | 1/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13354922 | 0.83 | FYN (0.59) | TTKERN1FYNLRRK2CCNA2 | |
| SCHEMBL15889905 | 0.80 | ERN1 (0.51) | TTKERN1FYNLRRK2CCNA2 | |
| SCHEMBL26833391 | 0.79 | ERN1 (0.47) | TTKERN1FYNLRRK2CCNA2 | |
| SCHEMBL12492042 | 0.79 | ALDH1A1 (0.62) | TTKERN1FYNLRRK2CCNA2 | |
| SCHEMBL16911398 | 0.77 | PDGFRB (0.49) | TTKERN1FYNLRRK2CCNA2 | |
| SCHEMBL15889368 | 0.77 | LRRK2 (0.48) | TTKERN1FYNLRRK2CCNA2 | |
| SCHEMBL20150208 | 0.76 | PIK3CD (0.49) | TTKLRRK2 | |
| SCHEMBL26123734 | 0.76 | PIK3CD (0.49) | TTKERN1FYNLRRK2CCNA2 | |
| SCHEMBL16911390 | 0.76 | LRRK2 (0.53) | TTKERN1FYNLRRK2CCNA2 | |
| SCHEMBL24731504 | 0.73 | PLAU (0.46) | TTKERN1FYNLRRK2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4227304-A2 | THIADIAZOLE ANALOGS AND THEIR USE FOR TREATING DISEASES ASSOCIATED WITH A DEFICIENCY OF SMN MOTOR NEURONS | Novartis AG (CH) | 2023-08-16 | — | — | EP | disclosed |
| EP-3736271-A1 | THIADIAZOLE ANALOGS AND THEIR USE FOR TREATING DISEASES ASSOCIATED WITH A DEFICIENCY OF SMN MOTOR NEURONS | Novartis AG (CH) | 2020-11-11 | — | — | EP | disclosed |