Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 4/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22642849 | 1.00 | PREP (0.56) | PREPCHRM1CHRM2CHRM3ELANE | |
| SCHEMBL22643309 | 1.00 | PREP (0.56) | PREPCHRM1CHRM2CHRM3ELANE | |
| SCHEMBL30147235 | 0.83 | PREP (0.62) | PREPCHRM1CHRM2CHRM3ELANE | |
| SCHEMBL22642834 | 0.83 | PREP (0.56) | PREPCHRM1CHRM2CHRM3ELANE | |
| SCHEMBL22642833 | 0.83 | PREP (0.56) | PREPCHRM1CHRM2CHRM3ELANE | |
| SCHEMBL22642802 | 0.83 | PREP (0.56) | PREPCHRM1CHRM2CHRM3ELANE | |
| SCHEMBL19186799 | 0.83 | PREP (0.56) | PREPCHRM1CHRM2CHRM3ELANE | |
| SCHEMBL22643297 | 0.83 | PREP (0.56) | PREPCHRM1CHRM2CHRM3ELANE | |
| SCHEMBL22643140 | 0.83 | PREP (0.56) | PREPCHRM1CHRM2CHRM3ELANE | |
| SCHEMBL22643111 | 0.83 | PREP (0.56) | PREPCHRM1CHRM2CHRM3ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970283-B1 | SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C | BOEHRINGER INGELHEIM INT (DE) | 2020-11-11 | — | — | EP | disclosed |