Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.36 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.36 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.36 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.36 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | ITK | Q08881 | 1/20 | 0.36 |
| ▸ | PASK | Q96RG2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10622670 | 0.89 | EGLN2 (0.41) | EGLN2DYRK1A | |
| SCHEMBL16075170 | 0.83 | EGLN2 (0.39) | EGLN2DYRK1A | |
| SCHEMBL30961665 | 0.78 | HDAC1 (0.50) | HDAC1HDAC3HDAC2NCOR2 | |
| SCHEMBL20051327 | 0.78 | HDAC1 (0.50) | HDAC1HDAC3HDAC2NCOR2 | |
| SCHEMBL7387168 | 0.74 | KDM4E (0.51) | HDAC1MAPK8MAPK9HDAC3HDAC2 | |
| SCHEMBL22430585 | 0.73 | HPGD (0.47) | EGLN2LMNADYRK1A | |
| SCHEMBL22367067 | 0.72 | ALDH1A1 (0.44) | HDAC1HDAC3HDAC2NCOR2LMNA | |
| SCHEMBL25121244 | 0.71 | TTR (0.35) | EGLN2 | |
| SCHEMBL4342782 | 0.71 | PDE4A (0.46) | EGLN2LMNADYRK1A | |
| SCHEMBL4805167 | 0.71 | HDAC1 (0.54) | HDAC1EGLN2LMNADYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970283-B1 | SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C | BOEHRINGER INGELHEIM INT (DE) | 2020-11-11 | — | — | EP | disclosed |