Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | CTSD | P07339 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | DNA2 | P51530 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | DTYMK | P23919 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL6223947 | 1.00 | TSHR (0.58) | TSHRTDP1L3MBTL1POLBKDM4E | |
| SCHEMBL282684 | 0.98 | TSHR (0.60) | TSHRTDP1L3MBTL1POLBKDM4E | |
| Ammonia Solution, Strong SCHEMBL5572312 | 0.88 | TDP1 (0.64) | TSHRTDP1L3MBTL1POLBKDM4E | |
| Ammonia Solution, Strong SCHEMBL5572316 | 0.88 | TDP1 (0.64) | TSHRTDP1L3MBTL1POLBKDM4E | |
| SCHEMBL1315874 | 0.88 | TDP1 (0.50) | TSHRTDP1L3MBTL1POLBCTSD | |
| Ammonia Solution, Strong SCHEMBL7650734 | 0.87 | TDP1 (0.58) | TSHRTDP1L3MBTL1POLBKDM4E | |
| Methane SCHEMBL28307885 | 0.86 | TDP1 (0.49) | TSHRTDP1L3MBTL1POLBCTSD | |
| SCHEMBL29351965 | 0.86 | TDP1 (0.66) | TSHRTDP1L3MBTL1POLBKDM4E | |
| SCHEMBL15869336 | 0.86 | TDP1 (0.66) | TSHRTDP1L3MBTL1POLBKDM4E | |
| SCHEMBL304456 | 0.86 | TDP1 (0.66) | TSHRTDP1L3MBTL1POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7994160-B2 | Pyridazine compounds as glycogen synthase kinase 3 inhibitors | ABBOTT GMBH & CO. KG (DE) | 2011-08-09 | — | — | US | disclosed |
| US-20090325937-A1 | Pyridazine Compounds as Glycogen Synthase Kinase 3 Inhibitors | ABBOTT GMBH & CO. KG (DE) | 2009-12-31 | — | — | US | disclosed |
| CN-1168727-C | Substituted benzimidazole | ���ĵ�˹ҩ��¹�����˾ | 2004-09-29 | — | — | CN | disclosed |
| CN-1356995-A | Substituted benzimidazole | AVENTIS PHARMA GMBH (DE) | 2002-07-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325937-A1 | Pyridazine Compounds as Glycogen Synthase Kinase 3 Inhibitors | GSK3B, GSK3A, GYS2 | TSHR 1845/4885TDP1 2925/4885L3MBTL1 2882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.