Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK6 | Q00534 | 17/20 | 0.80 |
| ▸ | CCND1 | P24385 | 11/20 | 0.80 |
| ▸ | CDK4 | P11802 | 8/20 | 0.80 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.58 |
| ▸ | CCND3 | P30281 | 5/20 | 0.56 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.56 |
| ▸ | CDK1 | P06493 | 3/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.56 |
| ▸ | CDK2 | P24941 | 3/20 | 0.56 |
| ▸ | CIT | O14578 | 1/20 | 0.56 |
| ▸ | GAK | O14976 | 1/20 | 0.56 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.56 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.56 |
| ▸ | STK16 | O75716 | 1/20 | 0.56 |
| ▸ | CCNK | O75909 | 1/20 | 0.56 |
| ▸ | STK10 | O94804 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Eciruciclib SCHEMBL29518577 | 0.89 | CDK6 (1.00) | CDK6CCND1CDK4DYRK2CCND3 | |
| Eciruciclib SCHEMBL17469895 | 0.89 | CDK6 (1.00) | CDK6CCND1CDK4DYRK2CCND3 | |
| Eciruciclib SCHEMBL29518576 | 0.89 | CDK6 (1.00) | CDK6CCND1CDK4DYRK2CCND3 | |
| Eciruciclib SCHEMBL23145129 | 0.88 | CDK6 (0.98) | CDK6CCND1CDK4DYRK2CCND3 | |
| SCHEMBL17469892 | 0.85 | CDK6 (0.81) | CDK6CCND1CDK4DYRK2CCND3 | |
| SCHEMBL19209843 | 0.85 | CDK6 (0.81) | CDK6CCND1CDK4DYRK2CCND3 | |
| SCHEMBL29518402 | 0.85 | CDK6 (0.81) | CDK6CCND1CDK4DYRK2CCND3 | |
| SCHEMBL17469754 | 0.83 | CDK6 (0.90) | CDK6CCND1CDK4DYRK2CCND3 | |
| SCHEMBL29518827 | 0.83 | CDK6 (0.90) | CDK6CCND1CDK4DYRK2CCND3 | |
| SCHEMBL29518408 | 0.83 | CDK6 (0.90) | CDK6CCND1CDK4DYRK2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |