Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.38 |
| ▸ | JAK3 | P52333 | 6/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 3/20 | 0.37 |
| ▸ | CCND1 | P24385 | 3/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.37 |
| ▸ | CDK2 | P24941 | 3/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 3/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650901 | 0.91 | CDK4 (0.45) | CDK4CCND1CCNA2CDK2CCNA1 | |
| SCHEMBL22650823 | 0.91 | CDK4 (0.45) | CDK4CCND1CCNA2CDK2CCNA1 | |
| SCHEMBL22650597 | 0.89 | EGFR (0.37) | JAK2JAK3CDK4CCND1CCNA2 | |
| SCHEMBL22650847 | 0.88 | JAK2 (0.39) | JAK2JAK3CDK4CCND1CCNA2 | |
| SCHEMBL22650423 | 0.86 | JAK2 (0.37) | JAK2JAK3IKBKBCHUKIKBKG | |
| SCHEMBL22650419 | 0.85 | JAK2 (0.38) | JAK2JAK3CDK4CCND1JAK1 | |
| SCHEMBL22650434 | 0.85 | JAK2 (0.36) | JAK2JAK3CDK4CCND1CDK2 | |
| SCHEMBL22650417 | 0.84 | CDK4 (0.40) | CDK4CCND1CCNA2CDK2CCNA1 | |
| SCHEMBL22650526 | 0.83 | MAP4K1 (0.44) | JAK2JAK3IKBKBCHUKCDK4 | |
| SCHEMBL22650851 | 0.83 | IKBKB (0.56) | IKBKBCHUKIKBKGCDK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |