SCHEMBL22650634

SCHEMBL22650634

COc1nc(-c2ccnc(Nc3ccc(N4CCC(N5CCOCC5)CC4=O)cn3)n2)cc2c1ncn2C(C)C

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
EGFR P00533 3/20 0.38
TTK P33981 1/20 0.38
CDK4 P11802 9/20 0.38
CCND1 P24385 7/20 0.38
CDK2 P24941 6/20 0.38
CDK6 Q00534 6/20 0.38
CCND3 P30281 5/20 0.38
CCNA2 P20248 4/20 0.38
CCNE1 P24864 2/20 0.36
IKBKE Q14164 1/20 0.35
TBK1 Q9UHD2 1/20 0.35
JAK2 O60674 3/20 0.35
JAK3 P52333 2/20 0.35
ALK Q9UM73 3/20 0.34
CDK1 P06493 1/20 0.34
CCNB1 P14635 1/20 0.34
JAK1 P23458 1/20 0.34
INSR P06213 1/20 0.34
IGF1R P08069 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22650514 0.94 CDK4 (0.38) CDK4CCND1CDK2CDK6CCND3
SCHEMBL22650590 0.91 CDK4 (0.35) EGFRCDK4CCND1CDK2CDK6
SCHEMBL22650859 0.84 CDK4 (0.51) CDK4CCND1CDK2CDK6CCND3
SCHEMBL22650546 0.82 CDK4 (0.42) CDK4CCND1CDK2CDK6CCND3
SCHEMBL22650776 0.82 CDK4 (0.36) CDK4CCND1CDK2CDK6CCND3
SCHEMBL22650513 0.81 CDK4 (0.36) CDK4CCND1CDK2CDK6CCND3
SCHEMBL22650429 0.81 CCND1 (0.40) CDK4CCND1CDK2CDK6CCND3
SCHEMBL22650520 0.80 TYK2 (0.40) CDK4CCND1CDK2CDK6CCND3
SCHEMBL22650560 0.79 CCND1 (0.36) CDK4CCND1CDK2CDK6CCND3
SCHEMBL22650615 0.79 CDK4 (0.46) TTKCDK4CCND1CDK2CDK6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020224568-A1 CDK INHIBITORS QILU REGOR THERAPEUTICS INC. (CN) 2020-11-12 WO disclosed