SCHEMBL22650520

SCHEMBL22650520

CC(C)n1cnc2c(OC(F)F)nc(-c3ccnc(Nc4ccc(N5CCOCC5=O)cn4)n3)cc21

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TYK2 P29597 2/20 0.40
CDK4 P11802 16/20 0.38
CDK6 Q00534 13/20 0.38
CCND1 P24385 10/20 0.38
CCND3 P30281 9/20 0.38
CCNA2 P20248 7/20 0.38
CDK2 P24941 7/20 0.38
JAK2 O60674 1/20 0.38
JAK1 P23458 1/20 0.38
JAK3 P52333 1/20 0.38
CDK1 P06493 3/20 0.37
CCNB1 P14635 2/20 0.37
CCNA1 P78396 1/20 0.37
CCNE1 P24864 1/20 0.34
CDK9 P50750 2/20 0.34
CCNT1 O60563 1/20 0.34
CDK7 P50613 1/20 0.34
CCNH P51946 1/20 0.34
MNAT1 P51948 1/20 0.34
CDK5 Q00535 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22650875 0.89 TYK2 (0.44) TYK2CDK4CDK6CCND1CCND3
SCHEMBL22650858 0.85 CDK4 (0.41) CDK4CDK6CCND1CCND3CCNA2
SCHEMBL22650949 0.82 CDK6 (0.45) TYK2CDK4CDK6CCND1CCND3
SCHEMBL22650634 0.80 EGFR (0.38) CDK4CDK6CCND1CCND3CCNA2
SCHEMBL22650948 0.80 CDK4 (0.46) TYK2CDK4CDK6CCND1CCND3
SCHEMBL22650859 0.80 CDK4 (0.51) CDK4CDK6CCND1CCND3CCNA2
SCHEMBL22650560 0.79 CCND1 (0.36) CDK4CDK6CCND1CCND3CCNA2
SCHEMBL22650513 0.79 CDK4 (0.36) CDK4CDK6CCND1CCND3CCNA2
SCHEMBL22650429 0.78 CCND1 (0.40) CDK4CDK6CCND1CCND3CCNA2
SCHEMBL22650579 0.76 CDK4 (0.48) CDK4CDK6CCND1CCND3CCNA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020224568-A1 CDK INHIBITORS QILU REGOR THERAPEUTICS INC. (CN) 2020-11-12 WO disclosed