Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 8/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21187297 | 0.89 | PRKDC (0.44) | PRKDCIRAK4PDE10ACCNCCDK8 | |
| SCHEMBL21187301 | 0.87 | PRKDC (0.35) | PRKDCIRAK4PDE10ACCNCCDK8 | |
| SCHEMBL30823305 | 0.86 | SYK (0.43) | PRKDCIRAK4PDE10ACCNCCDK8 | |
| SCHEMBL21187258 | 0.86 | SYK (0.43) | PRKDCIRAK4PDE10ACCNCCDK8 | |
| SCHEMBL21177847 | 0.86 | SYK (0.43) | PRKDCIRAK4PDE10ACCNCCDK8 | |
| SCHEMBL21179454 | 0.86 | ERBB2 (0.38) | PRKDCCCNCCDK8KCNH2TBK1 | |
| SCHEMBL21179453 | 0.86 | ERBB2 (0.38) | PRKDCCCNCCDK8KCNH2TBK1 | |
| SCHEMBL21178261 | 0.85 | ERBB2 (0.40) | PRKDCIRAK4KCNH2ERBB2 | |
| SCHEMBL21187311 | 0.85 | ERBB2 (0.40) | PRKDCIRAK4KCNH2ERBB2 | |
| Hydrochloric Acid SCHEMBL30823284 | 0.85 | PRKDC (0.44) | PRKDCPDE10ACCNCCDK8KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200353101-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED | 2020-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200353101-A1 | DNA-PK INHIBITORS | POLK, DTYMK, DCK | PRKDC 34/4885IRAK4 1175/4885PDE10A 1271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.