Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 4/20 | 0.69 |
| ▸ | ABL1 | P00519 | 7/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KLK7 | P49862 | 1/20 | 0.47 |
| ▸ | KRAS | P01116 | 3/20 | 0.45 |
| ▸ | BRAF | P15056 | 3/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | ARAF | P10398 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22652907 | 0.87 | ABL1 (0.58) | RAF1ABL1RAB9ANPC1L3MBTL1 | |
| SCHEMBL22625498 | 0.87 | RAF1 (0.63) | RAF1ABL1RAB9ANPC1L3MBTL1 | |
| SCHEMBL23745178 | 0.85 | RAF1 (0.75) | RAF1ABL1RAB9ANPC1HTT | |
| SCHEMBL22612839 | 0.84 | RAF1 (0.79) | RAF1ABL1KRASBRAFKDR | |
| SCHEMBL30439766 | 0.84 | RAF1 (0.79) | RAF1ABL1KRASBRAFKDR | |
| SCHEMBL22612951 | 0.83 | RAF1 (0.65) | RAF1ABL1KRASBRAFKDR | |
| SCHEMBL29427286 | 0.83 | RAF1 (0.65) | RAF1ABL1KRASBRAFKDR | |
| SCHEMBL22612814 | 0.82 | RAF1 (0.75) | RAF1BRAF | |
| SCHEMBL22625553 | 0.82 | RAF1 (0.75) | RAF1ABL1KRASBRAFKDR | |
| SCHEMBL22612954 | 0.82 | RAF1 (0.71) | RAF1ABL1KRASBRAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020227020-A1 | INHIBITORS OF RAF KINASES | KINNATE BIOPHARMA INC. (US) | 2020-11-12 | — | — | WO | disclosed |