Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 9/20 | 0.58 |
| ▸ | RAF1 | P04049 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 4/20 | 0.46 |
| ▸ | LCK | P06239 | 3/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KLK7 | P49862 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KRAS | P01116 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23745180 | 0.91 | ABL1 (0.59) | ABL1RAF1NPC1KDRLCK | |
| SCHEMBL22652906 | 0.87 | RAF1 (0.69) | ABL1RAF1RAB9ANPC1HTT | |
| SCHEMBL22625576 | 0.87 | RAF1 (0.60) | ABL1RAF1KDRLCKMAPK14 | |
| SCHEMBL22612789 | 0.84 | RAF1 (0.63) | ABL1RAF1KDRLCKMAPK14 | |
| SCHEMBL29427251 | 0.84 | RAF1 (0.63) | ABL1RAF1KDRLCKMAPK14 | |
| SCHEMBL22612832 | 0.84 | RAF1 (0.63) | ABL1RAF1KDRLCKMAPK14 | |
| SCHEMBL22612799 | 0.84 | RAF1 (0.63) | ABL1RAF1KDRLCKMAPK14 | |
| SCHEMBL29427253 | 0.84 | RAF1 (0.63) | ABL1RAF1KDRLCKMAPK14 | |
| SCHEMBL22612716 | 0.82 | RAF1 (0.61) | ABL1RAF1KDRLCKMAPK14 | |
| SCHEMBL22612850 | 0.82 | BRAF (0.57) | ABL1RAF1KDRLCKMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020227020-A1 | INHIBITORS OF RAF KINASES | KINNATE BIOPHARMA INC. (US) | 2020-11-12 | — | — | WO | disclosed |