Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 0.43 |
| ▸ | RAF1 | P04049 | 4/20 | 0.43 |
| ▸ | KDR | P35968 | 4/20 | 0.43 |
| ▸ | KRAS | P01116 | 3/20 | 0.43 |
| ▸ | ABL1 | P00519 | 5/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 2/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | ARAF | P10398 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.33 |
| ▸ | CSK | P41240 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29877852 | 0.83 | KDR (0.45) | BRAFRAF1KDRKRASABL1 | |
| SCHEMBL22625601 | 0.79 | KDR (0.42) | BRAFRAF1KDRKRASABL1 | |
| SCHEMBL26165508 | 0.78 | ABL1 (0.38) | RAF1ABL1IRAK4VRK1DHFR | |
| SCHEMBL16667723 | 0.78 | KDR (0.55) | BRAFRAF1KDRKRASABL1 | |
| SCHEMBL15269293 | 0.77 | BRAF (0.45) | BRAFRAF1KDRKRASABL1 | |
| SCHEMBL30236557 | 0.76 | ABL1 (0.46) | BRAFRAF1KDRKRASABL1 | |
| SCHEMBL29272259 | 0.73 | ABL1 (0.41) | BRAFRAF1ABL1LCKIRAK4 | |
| SCHEMBL30236700 | 0.73 | ABL1 (0.41) | BRAFRAF1ABL1LCKIRAK4 | |
| SCHEMBL24457808 | 0.71 | MAP4K4 (0.56) | BRAFRAF1KDRKRASABL1 | |
| SCHEMBL24457875 | 0.70 | BRAF (0.48) | BRAFRAF1KDRKRASABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210246135-A1 | INHIBITORS OF RAF KINASES | Pierre Fabre Médicament (FR) | 2021-08-12 | — | — | US | disclosed |
| WO-2020227020-A1 | INHIBITORS OF RAF KINASES | KINNATE BIOPHARMA INC. (US) | 2020-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210246135-A1 | INHIBITORS OF RAF KINASES | BRAF, RAF1, NRAS | BRAF 1/4885RAF1 2/4885KDR 113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.