Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 9/20 | 0.46 |
| ▸ | RAF1 | P04049 | 7/20 | 0.37 |
| ▸ | BRAF | P15056 | 6/20 | 0.37 |
| ▸ | KRAS | P01116 | 4/20 | 0.37 |
| ▸ | KDR | P35968 | 4/20 | 0.37 |
| ▸ | ARAF | P10398 | 2/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.33 |
| ▸ | NNMT | P40261 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30236572 | 0.83 | ABL1 (0.40) | ABL1RAF1BRAFKRASKDR | |
| SCHEMBL30236413 | 0.83 | ABL1 (0.36) | ABL1RAF1BRAFKRASKDR | |
| SCHEMBL30236310 | 0.80 | MAP4K1 (0.37) | ABL1RAF1BRAFKRASKDR | |
| SCHEMBL29272181 | 0.80 | MAP4K1 (0.37) | ABL1RAF1BRAFKRASKDR | |
| SCHEMBL30237345 | 0.79 | ABL1 (0.54) | ABL1BRAFKDRNNMTLCK | |
| SCHEMBL30236608 | 0.79 | PDGFRB (0.39) | ABL1RAF1BRAFKRASKDR | |
| SCHEMBL29272099 | 0.79 | PDGFRB (0.39) | ABL1RAF1BRAFKRASKDR | |
| SCHEMBL15289623 | 0.78 | RAF1 (0.40) | ABL1RAF1BRAFKRASKDR | |
| SCHEMBL22652911 | 0.76 | BRAF (0.43) | ABL1RAF1BRAFKRASKDR | |
| SCHEMBL30236419 | 0.76 | ABL1 (0.41) | ABL1RAF1BRAFKRASKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4399210-A1 | 6-AZA-QUINOLINE DERIVATIVES AND RELATED USES | Black Diamond Therapeutics, Inc. (US) | 2024-07-17 | — | — | EP | disclosed |
| CN-118159537-A | 6-Aza-quinoline derivatives and related uses | 黑钻治疗公司 | 2024-06-07 | — | — | CN | disclosed |
| WO-2023039505-A1 | 6-AZA-QUINOLINE DERIVATIVES AND RELATED USES | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2023-03-16 | — | — | WO | disclosed |