Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | KRAS | P01116 | 2/20 | 0.41 |
| ▸ | RAF1 | P04049 | 2/20 | 0.41 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 9/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | BLK | P51451 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22652928 | 0.90 | KDR (0.44) | ALDH1A1KDRKRASRAF1BRAF | |
| SCHEMBL22625559 | 0.89 | RAF1 (0.43) | ALDH1A1KDRKRASRAF1BRAF | |
| SCHEMBL22625561 | 0.84 | KDR (0.59) | ALDH1A1KDRKRASRAF1BRAF | |
| SCHEMBL22625605 | 0.82 | RAF1 (0.49) | ALDH1A1KDRKRASRAF1BRAF | |
| SCHEMBL22625543 | 0.75 | BRAF (0.60) | ALDH1A1KDRKRASRAF1BRAF | |
| SCHEMBL24367126 | 0.74 | ALDH1A1 (0.55) | ALDH1A1TSHRRAB9ASMN1; SMN2BTK | |
| SCHEMBL22612837 | 0.72 | LCK (0.65) | KDRRAF1BRAFJAK3LCK | |
| SCHEMBL22625600 | 0.72 | ALDH1A1 (0.37) | ALDH1A1TSHRRAB9ASMN1; SMN2BTK | |
| SCHEMBL22625601 | 0.71 | KDR (0.42) | KDRKRASRAF1BRAFJAK3 | |
| SCHEMBL22612778 | 0.71 | LCK (0.47) | KDRKRASRAF1BRAFJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11667634-B2 | Inhibitors of RAF kinases | KINNATE BIOPHARMA INC. (US) | 2023-06-06 | — | — | US | disclosed |
| WO-2020227020-A1 | INHIBITORS OF RAF KINASES | KINNATE BIOPHARMA INC. (US) | 2020-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11667634-B2 | Inhibitors of RAF kinases | BRAF, RAF1, NRAS | ALDH1A1 3044/4885KDR 113/4885KRAS 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.