SCHEMBL22653544

SCHEMBL22653544

CC(C)(C)OC(=O)N1CCN(C(=O)CC(CSc2ccccc2)Nc2ccc(S(N)(=O)=O)cc2S(=O)(=O)C(F)(F)F)CC1

nearest known ligand 0.60

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ BCL2L1 Q07817 18/20 0.60
▸ SFRP1 Q8N474 2/20 0.43
▸ BCL2 P10415 14/20 0.41
▸ MCL1 Q07820 1/20 0.40
▸ BCL2L2 Q92843 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22653545 1.00 BCL2L1 (0.60) BCL2L1SFRP1BCL2MCL1BCL2L2
SCHEMBL22581289 0.90 BCL2L1 (0.66) BCL2L1BCL2
SCHEMBL28716010 0.90 BCL2L1 (0.66) BCL2L1BCL2
SCHEMBL22581205 0.90 BCL2L1 (0.74) BCL2L1BCL2
SCHEMBL22581203 0.90 BCL2L1 (0.74) BCL2L1BCL2
SCHEMBL554919 0.88 BCL2L1 (0.75) BCL2L1BCL2
SCHEMBL554918 0.88 BCL2L1 (0.75) BCL2L1BCL2
SCHEMBL15514753 0.86 BCL2L1 (0.61) BCL2L1BCL2MCL1BCL2L2
SCHEMBL15514754 0.86 BCL2L1 (0.61) BCL2L1BCL2MCL1BCL2L2
SCHEMBL26648676 0.85 BCL2L1 (0.67) BCL2L1BCL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE50643-E1 Benzamide compounds RECURIUM IP HOLDINGS, LLC (US) 2025-10-21 — — US disclosed
EP-4556469-A1 BENZAMIDE COMPOUNDS Recurium IP Holdings, LLC (US) 2025-05-21 — — EP disclosed
EP-3740487-B1 BENZAMIDE COMPOUNDS AS BCI INHIBITORS FOR THE TREATMENT OF HIV RECURIUM IP HOLDINGS LLC (US) 2025-01-08 — — EP disclosed
US-20240180899-A1 BENZAMIDE COMPOUNDS RECURIUM IP HOLDINGS, LLC 2024-06-06 — — US disclosed
CN-118084904-A Benzamide compounds 里科瑞尔姆IP控股有限责任公司 2024-05-28 — — CN disclosed
CN-118084905-A Benzamide compounds 里科瑞尔姆IP控股有限责任公司 2024-05-28 — — CN disclosed
CN-111801327-B Benzamide compounds 里科瑞尔姆IP控股有限责任公司 2024-02-09 — — CN disclosed
US-11813259-B2 Benzamide compounds RECURIUM IP HOLDINGS, LLC (US) 2023-11-14 — — US disclosed
US-11813260-B1 Benzamide compounds RECURIUM IP HOLDINGS, LLC (US) 2023-11-14 — — US disclosed
US-20230167105-A1 BCL-2 PROTEIN INHIBITORS RECURIUM IP HOLDINGS, LLC 2023-06-01 — — US disclosed
US-11590126-B2 Benzamide compounds RECURIUM IP HOLDINGS, LLC (US) 2023-02-28 — — US disclosed
US-20220273666-A1 NANOPARTICLE FORMULATION OF BCL-2 INHIBITOR RECURIUM IP HOLDINGS, LLC 2022-09-01 — — US disclosed
US-20220265834-A1 BCL-2 PROTEIN INHIBITORS RECURIUM IP HOLDINGS, LLC 2022-08-25 — — US disclosed
US-20220226314-A1 BENZAMIDE COMPOUNDS RECURIUM IP HOLDINGS, LLC 2022-07-21 — — US disclosed
US-11344546-B2 Benzamide compounds Recurium IP Holding, LLC (US) 2022-05-31 — — US disclosed
US-11318134-B2 Benzamide compounds RECURIUM IP HOLDINGS, LLC (US) 2022-05-03 — — US disclosed
EP-3740487-A1 BENZAMIDE COMPOUNDS Recurium IP Holdings, LLC (US) 2020-11-25 — — EP disclosed
EP-3737672-A1 BENZAMIDE COMPOUNDS Recurium IP Holdings, LLC (US) 2020-11-18 — — EP disclosed
EP-3737681-A1 BENZAMIDE COMPOUNDS Recurium IP Holdings, LLC (US) 2020-11-18 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11813259-B2 Benzamide compounds MKI67, TMBIM6, HDAC1 BCL2L1 86/4885SFRP1 4654/4885BCL2 69/4885
US-11813260-B1 Benzamide compounds MKI67, TMBIM6, HDAC1 BCL2L1 86/4885SFRP1 4654/4885BCL2 69/4885
US-20220265834-A1 BCL-2 PROTEIN INHIBITORS BCL2, BCL2L1, BCL2L2 BCL2L1 2/4885SFRP1 3516/4885BCL2 1/4885
US-11590126-B2 Benzamide compounds MKI67, TMBIM6, HDAC1 BCL2L1 86/4885SFRP1 4654/4885BCL2 69/4885
US-11318134-B2 Benzamide compounds MKI67, TMBIM6, HDAC1 BCL2L1 86/4885SFRP1 4654/4885BCL2 69/4885
US-20220273666-A1 NANOPARTICLE FORMULATION OF BCL-2 INHIBITOR BCL2, BCL2L2, BCL2L1 BCL2L1 3/4885SFRP1 1699/4885BCL2 1/4885
US-20220226314-A1 BENZAMIDE COMPOUNDS MKI67, TMBIM6, HDAC1 BCL2L1 86/4885SFRP1 4654/4885BCL2 69/4885
US-20240180899-A1 BENZAMIDE COMPOUNDS MKI67, TMBIM6, HDAC1 BCL2L1 86/4885SFRP1 4654/4885BCL2 69/4885
US-11344546-B2 Benzamide compounds MKI67, TMBIM6, HDAC1 BCL2L1 86/4885SFRP1 4654/4885BCL2 69/4885
US-20230167105-A1 BCL-2 PROTEIN INHIBITORS BCL2, BCL2L1, BCL2L2 BCL2L1 2/4885SFRP1 3578/4885BCL2 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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