Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.47 |
| ▸ | PDE2A | O00408 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17645962 | 0.81 | HDAC3 (0.40) | HDAC1HDAC3HDAC2HDAC6PDE2A | |
| SCHEMBL22438947 | 0.80 | HDAC1 (0.49) | HDAC1HDAC3HDAC2HDAC6NPC1 | |
| SCHEMBL28506049 | 0.76 | LPL (0.43) | HDAC1HDAC3HDAC2HDAC6PDE2A | |
| SCHEMBL22439020 | 0.75 | HDAC1 (0.48) | HDAC1HDAC3HDAC2HDAC6NPC1 | |
| SCHEMBL5517439 | 0.74 | AAK1 (0.45) | HDAC1HDAC3HDAC2HDAC6PDE2A | |
| SCHEMBL34469713 | 0.74 | AAK1 (0.45) | HDAC1HDAC3HDAC2HDAC6PDE2A | |
| SCHEMBL29985872 | 0.73 | PDE2A (0.37) | PDE2ANPC1POLBSMN1; SMN2MEN1 | |
| SCHEMBL22657416 | 0.71 | HDAC1 (0.41) | HDAC1HDAC3HDAC2HDAC6PDE2A | |
| SCHEMBL23908270 | 0.71 | WDR91 (0.56) | HDAC1HDAC3HDAC2HDAC6NPC1 | |
| SCHEMBL3848169 | 0.71 | MAPT (0.67) | HDAC1NPC1POLBSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112047877-A | Novel amide compound and use thereof | 和记黄埔医药（上海）有限公司 | 2020-12-08 | — | — | CN | disclosed |
| WO-2020228823-A1 | NOVEL AMIDE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2020-11-19 | — | — | WO | disclosed |
| WO-2020228823-A1 | NOVEL AMIDE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2020-11-19 | — | — | WO | disclosed |