Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL654449 | 0.87 | TSHR (0.52) | HTTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL897060 | 0.81 | HTT (0.52) | HTTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL18725495 | 0.80 | HTT (0.47) | HTTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL5491264 | 0.80 | ALDH1A1 (0.58) | HTTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL12776963 | 0.80 | HTT (0.51) | HTTMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL23499773 | 0.79 | ALDH1A1 (0.51) | HTTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL2100704 | 0.79 | ALDH1A1 (0.52) | HTTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL28413881 | 0.79 | TDP1 (0.55) | HTTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL1530547 | 0.78 | HTT (0.53) | HTTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL2434367 | 0.77 | HTT (0.61) | HTTLMNAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3969439-A1 | ACSS2 INHIBITORS AND METHODS OF USE THEREOF | Metabomed Ltd (IL) | 2022-03-23 | — | — | EP | disclosed |
| WO-2020230134-A1 | ACSS2 INHIBITORS AND METHODS OF USE THEREOF | METABOMED LTD (IL) | 2020-11-19 | — | — | WO | disclosed |