Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | BUB1 | O43683 | 1/20 | 0.44 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 9/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22659636 | 0.91 | ABL1 (0.48) | TYK2MAP4K1ABL1 | |
| SCHEMBL22659633 | 0.91 | ABL1 (0.48) | TYK2MAP4K1ABL1 | |
| SCHEMBL29532924 | 0.88 | ABL1 (0.42) | TYK2BUB1MAP4K1ABL1GSK3B | |
| SCHEMBL22659490 | 0.88 | ABL1 (0.42) | TYK2BUB1MAP4K1ABL1GSK3B | |
| SCHEMBL29533400 | 0.88 | ABL1 (0.42) | TYK2BUB1MAP4K1ABL1GSK3B | |
| SCHEMBL22659499 | 0.88 | ABL1 (0.42) | TYK2BUB1MAP4K1ABL1GSK3B | |
| Hydrochloric Acid SCHEMBL22660110 | 0.86 | TYK2 (0.45) | TYK2BUB1MAP4K1ABL1GSK3B | |
| Hydrochloric Acid SCHEMBL29533334 | 0.86 | TYK2 (0.45) | TYK2BUB1MAP4K1ABL1GSK3B | |
| Hydrochloric Acid SCHEMBL22659439 | 0.86 | TYK2 (0.45) | TYK2BUB1MAP4K1ABL1GSK3B | |
| Hydrochloric Acid SCHEMBL29533214 | 0.86 | TYK2 (0.45) | TYK2BUB1MAP4K1ABL1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020232330-A1 | INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE | BIOGEN MA INC. (US) | 2020-11-19 | — | — | WO | disclosed |