⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9887136 | 0.87 | NOS1 (0.32) | — | |
| SCHEMBL15865750 | 0.81 | — | — | |
| SCHEMBL11739358 | 0.69 | KDM4E (0.36) | — | |
| SCHEMBL10598394 | 0.68 | — | — | |
| SCHEMBL59379 | 0.65 | KDM4E (0.37) | — | |
| SCHEMBL31272835 | 0.65 | — | — | |
| SCHEMBL5176499 | 0.65 | — | — | |
| SCHEMBL10929891 | 0.64 | — | — | |
| SCHEMBL10596388 | 0.64 | — | — | |
| SCHEMBL13370172 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230295070-A1 | Modulators of Liver Receptor Homologue 1 (LRH-1) and Uses | EMORY UNIVERSITY | 2023-09-21 | — | — | US | disclosed |
| US-11691939-B2 | Modulators of liver receptor homologue 1 (LRH-1) and uses | EMORY UNIVERSITY (US) | 2023-07-04 | — | — | US | disclosed |
| US-10843996-B2 | Modulators of liver receptor homologue 1 (LRH-1) and uses | EMORY UNIVERSITY (US) | 2020-11-24 | — | — | US | disclosed |