Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.45 |
| ▸ | GSK3B | P49841 | 14/20 | 0.45 |
| ▸ | CDK1 | P06493 | 3/20 | 0.45 |
| ▸ | CDK2 | P24941 | 3/20 | 0.45 |
| ▸ | CDK9 | P50750 | 3/20 | 0.45 |
| ▸ | CDK3 | Q00526 | 3/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.45 |
| ▸ | GSK3A | P49840 | 3/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29533697 | 1.00 | PIK3C3 (0.45) | PIK3C3GSK3BCDK1CDK2CDK9 | |
| SCHEMBL29533370 | 0.90 | GSK3B (0.45) | PIK3C3GSK3BCDK1CDK2CDK9 | |
| SCHEMBL22664857 | 0.90 | GSK3B (0.45) | PIK3C3GSK3BCDK1CDK2CDK9 | |
| SCHEMBL22659397 | 0.86 | GSK3B (0.47) | PIK3C3GSK3BCDK1CDK2CDK9 | |
| SCHEMBL22664601 | 0.85 | GSK3B (0.47) | PIK3C3GSK3BMAPK8MAPK10 | |
| SCHEMBL29533456 | 0.85 | GSK3B (0.47) | PIK3C3GSK3BMAPK8MAPK10 | |
| SCHEMBL22664712 | 0.85 | TYK2 (0.52) | PIK3C3GSK3BCDK1CDK2CDK9 | |
| SCHEMBL29533271 | 0.83 | GSK3B (0.45) | PIK3C3GSK3BCDK1CDK2CDK9 | |
| SCHEMBL22664610 | 0.83 | GSK3B (0.45) | PIK3C3GSK3BCDK1CDK2CDK9 | |
| SCHEMBL22660077 | 0.82 | GSK3B (0.48) | PIK3C3GSK3BMAPK14MAPK8MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020232330-A1 | INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE | BIOGEN MA INC. (US) | 2020-11-19 | — | — | WO | disclosed |