Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 3/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29533456 | 1.00 | GSK3B (0.47) | GSK3BALDH1A1PIK3C3TYK2MAPK8 | |
| SCHEMBL29533531 | 0.89 | GSK3B (0.48) | GSK3BPIK3C3MAPK8MAPK10 | |
| SCHEMBL22660077 | 0.89 | GSK3B (0.48) | GSK3BPIK3C3MAPK8MAPK10 | |
| SCHEMBL22664697 | 0.87 | EPHX2 (0.51) | GSK3BPIK3C3MAPK8MAPK10KDR | |
| SCHEMBL29532964 | 0.87 | EPHX2 (0.51) | GSK3BPIK3C3MAPK8MAPK10KDR | |
| SCHEMBL22664629 | 0.85 | PIK3C3 (0.45) | GSK3BPIK3C3MAPK8MAPK10 | |
| SCHEMBL29533697 | 0.85 | PIK3C3 (0.45) | GSK3BPIK3C3MAPK8MAPK10 | |
| SCHEMBL22659464 | 0.84 | GSK3B (0.54) | GSK3BPIK3C3TYK2MAPK8MAPK10 | |
| SCHEMBL22664857 | 0.82 | GSK3B (0.45) | GSK3BPIK3C3MAPK8MAPK10 | |
| SCHEMBL29533370 | 0.82 | GSK3B (0.45) | GSK3BPIK3C3MAPK8MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020232330-A1 | INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE | BIOGEN MA INC. (US) | 2020-11-19 | — | — | WO | disclosed |