SCHEMBL2266526

SCHEMBL2266526

O=C1c2ccccc2-c2nc3ccccc3n21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 3/20 1.00
KDM4E B2RXH2 4/20 0.64
ALDH1A1 P00352 3/20 0.64
HPGD P15428 2/20 0.64
RECQL P46063 1/20 0.53
ESR1 P03372 3/20 0.48
ESR2 Q92731 3/20 0.48
TSHR P16473 2/20 0.45
NPC1 O15118 2/20 0.45
KMT2A Q03164 2/20 0.45
PKM P14618 2/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
TP53 P04637 1/20 0.45
HSD17B10 Q99714 1/20 0.45
MEN1 O00255 1/20 0.45
HTT P42858 2/20 0.44
MAPK1 P28482 1/20 0.44
LMNA P02545 3/20 0.44
MAPT P10636 3/20 0.43
NTRK1 P04629 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29624740 1.00 RAB9A (1.00) RAB9AKDM4EALDH1A1HPGDRECQL
SCHEMBL5473377 0.85 RAB9A (0.73) RAB9AKDM4EALDH1A1HPGDRECQL
SCHEMBL13547667 0.84 RAB9A (0.71) RAB9AKDM4EALDH1A1HPGDRECQL
SCHEMBL5468221 0.83 RAB9A (0.71) RAB9AKDM4EALDH1A1HPGDRECQL
SCHEMBL13260865 0.82 RAB9A (0.68) RAB9AKDM4EALDH1A1HPGDRECQL
SCHEMBL13547663 0.82 RAB9A (0.69) RAB9AKDM4EALDH1A1HPGDESR1
SCHEMBL13547606 0.81 RAB9A (0.68) RAB9AKDM4EALDH1A1HPGDRECQL
SCHEMBL14128970 0.81 RAB9A (0.68) RAB9AKDM4EALDH1A1HPGDRECQL
SCHEMBL13936053 0.81 RAB9A (0.68) RAB9AKDM4EALDH1A1HPGDRECQL
SCHEMBL22955863 0.80 RAB9A (0.67) RAB9AKDM4EALDH1A1HPGDNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0968254-B1 FLUORESCENT MATERIALS AND THEIR USE CIBA SC HOLDING AG (CH) 2004-09-15 EP claimed
US-20030023097-A1 Fluorescent materials and their use OTANI JUNJI (JP) 2003-01-30 US claimed
EP-0963425-B1 FLUORESCENT COMPOSITIONS AND THEIR USE CIBA SC HOLDING AG (CH) 2002-04-24 EP claimed
EP-0968253-B1 FLUORESCENT HOST-GUEST-SYSTEM CIBA SC HOLDING AG (CH) 2002-02-13 EP claimed
EP-0963426-B1 FLUORESCENT CHROMOPHORE, COVALENTLY LINKED TO AN ORGANIC SUPPORT MATERIAL CIBA SC HOLDING AG (CH) 2001-10-24 EP claimed
US-20010016269-A1 FLUORESCENT MATERIALS AND THEIR USE CIBA SPECIALTY CHEMICALS CORP. 2001-08-23 US claimed
US-6146809-A FLUORESCENCE EMISSION SPECTRUM OF THE HOST CHROMOPHORE OVERLAPS WITH THE ABSORPTION SPECTRUM OF THE GUEST CHROMOPHORE CIBA SPECIALTY CHEMICALS CORPORATION (US) 2000-11-14 US claimed
US-6103446-A CHROMOPHORES OF BENZO(4,5)IMIDAZO(2,1-A)ISOINDOL-11-ONES COVALENTLY LINKED TO ACRYLATE POLYMERS; RELIEF IMAGES; SOLID-STATE FLUORESCENCE WITH A HIGH EMISSION INTENSITY CIBA SPECIALTY CHEMICALS CORPORATION (US) 2000-08-15 US claimed
EP-0968254-A1 FLUORESCENT MATERIALS AND THEIR USE Ciba SC Holding AG (CH) 2000-01-05 EP claimed
WO-1998033862-A1 FLUORESCENT MATERIALS AND THEIR USE CIBA SPECIALITY CHEMICALS HOLDING INC. (CH) 1998-08-06 WO claimed
EP-2362731-B1 NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL ANTI-DIABETIC AGENTS MERCK SHARP & DOHME (US) 2016-04-06 EP disclosed
EP-2352374-B1 NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL ANTI-DIABETIC AGENTS MERCK SHARP & DOHME (US) 2014-09-24 EP disclosed
US-8563746-B2 Cyclic benzimidazole derivatives useful as anti-diabetic agents MERCK SHARP & DOHME CORP (US) 2013-10-22 US disclosed
US-8329914-B2 Cyclic benzimidazole derivatives useful as anti-diabetic agents MERCK SHARP & DOHME CORP (US) 2012-12-11 US disclosed
CN-102271511-A Novel cyclic benzimidazole derivatives useful anti-diabetic agents 2011-12-07 CN disclosed
WO-1998033862-A1 FLUORESCENT MATERIALS AND THEIR USE CIBA SPECIALITY CHEMICALS HOLDING INC. (CH) 1998-08-06 WO disclosed
WO-1998033862-A1 FLUORESCENT MATERIALS AND THEIR USE CIBA SPECIALITY CHEMICALS HOLDING INC. (CH) 1998-08-06 WO disclosed
WO-1998033865-A1 FLUORESCENT CHROMOPHORE, COVALENTLY LINKED TO AN ORGANIC SUPPORT MATERIAL CIBA SPECIALTY CHEMICALS HOLDING, INC. (CH) 1998-08-06 WO disclosed
WO-1998033864-A1 FLUORESCENT COMPOSITIONS AND THEIR USE CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 1998-08-06 WO disclosed
US-4623379-A Plant growth and development modification using 2-(2-oxycarbonylphenyl)benzimidazole derivatives FMC CORPORATION (US) 1986-11-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030023097-A1 Fluorescent materials and their use VCL, VIM, COL14A1 RAB9A 1669/4885KDM4E 4210/4885ALDH1A1 788/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.