Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 20/20 | 0.74 |
| ▸ | HCRTR2 | O43614 | 20/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29521524 | 1.00 | HCRTR1 (0.74) | HCRTR1HCRTR2KCNH2 | |
| SCHEMBL24533939 | 1.00 | HCRTR1 (0.74) | HCRTR1HCRTR2KCNH2 | |
| SCHEMBL2116763 | 1.00 | HCRTR1 (0.74) | HCRTR1HCRTR2KCNH2 | |
| SCHEMBL26350991 | 0.92 | HCRTR1 (0.74) | HCRTR1HCRTR2KCNH2 | |
| SCHEMBL16638936 | 0.92 | HCRTR1 (0.74) | HCRTR1HCRTR2KCNH2 | |
| SCHEMBL26350983 | 0.92 | HCRTR1 (0.74) | HCRTR1HCRTR2KCNH2 | |
| SCHEMBL2610558 | 0.92 | HCRTR1 (0.74) | HCRTR1HCRTR2KCNH2 | |
| SCHEMBL26351279 | 0.92 | HCRTR1 (0.74) | HCRTR1HCRTR2KCNH2 | |
| SCHEMBL26350998 | 0.91 | HCRTR1 (0.73) | HCRTR1HCRTR2KCNH2 | |
| SCHEMBL28928604 | 0.90 | HCRTR1 (0.75) | HCRTR1HCRTR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023178702-A1 | METHOD FOR PREPARING LEMBOREXANT AND METHOD FOR PREPARING LEMBOREXANT INTERMEDIATE COMPOUND | 浙江华海药业股份有限公司 | 2023-09-28 | — | — | WO | disclosed |
| CN-114901285-A | Raw material medicine of Leboraseng and medicine composition containing same | 卫材R&D管理有限公司 | 2022-08-12 | — | — | CN | disclosed |
| WO-2020230800-A1 | METHOD AND COMPOUND USEFUL IN PREPARATION OF OREXIN-2 RECEPTOR ANTAGONIST, AND LEMBOREXANT HAVING FEW IMPURITIES | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 2020-11-19 | — | — | WO | disclosed |