Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 10/20 | 0.68 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | ADH1B | P00325 | 1/20 | 0.38 |
| ▸ | ADH1C | P00326 | 1/20 | 0.38 |
| ▸ | ADH1A | P07327 | 1/20 | 0.38 |
| ▸ | ADH4 | P08319 | 1/20 | 0.38 |
| ▸ | ADH7 | P40394 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21579003 | 0.95 | EPHX1 (0.61) | EPHX1TSHRALDH1A1S1PR2S1PR4 | |
| SCHEMBL21398350 | 0.95 | EPHX1 (0.61) | EPHX1TSHRALDH1A1S1PR2S1PR4 | |
| SCHEMBL20644846 | 0.95 | EPHX1 (0.61) | EPHX1TSHRALDH1A1S1PR2S1PR4 | |
| SCHEMBL22403813 | 0.93 | EPHX1 (0.56) | EPHX1TSHRALDH1A1S1PR2S1PR4 | |
| SCHEMBL22111696 | 0.93 | EPHX1 (0.56) | EPHX1TSHRALDH1A1S1PR2S1PR4 | |
| SCHEMBL23746602 | 0.91 | EPHX1 (0.54) | EPHX1TSHRALDH1A1S1PR2S1PR4 | |
| SCHEMBL17424948 | 0.91 | EPHX1 (0.54) | EPHX1S1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL24042407 | 0.89 | EPHX1 (0.52) | EPHX1S1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL20629328 | 0.88 | EPHX1 (0.50) | EPHX1TSHRALDH1A1SIGMAR1 | |
| SCHEMBL20975781 | 0.88 | EPHX1 (0.50) | EPHX1TSHRALDH1A1S1PR2S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3519385-B1 | CYANOPYRROLIDINE DERIVATIVES WITH ACTIVITY AS INHIBITORS OF USP30 | MISSION THERAPEUTICS LTD (GB) | 2020-11-18 | — | — | EP | disclosed |