Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.44 |
| ▸ | CPS1 | P31327 | 2/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22668974 | 0.86 | HTR2A (0.46) | HRH3DRD2HTR2AHTR2CKCNH2 | |
| SCHEMBL3782401 | 0.83 | HRH3 (0.65) | HRH3 | |
| SCHEMBL3782396 | 0.83 | HRH3 (0.65) | HRH3 | |
| SCHEMBL22669096 | 0.81 | HRH3 (0.49) | HRH3HTR2AKCNH2MAOAMAOB | |
| SCHEMBL22668968 | 0.79 | HRH3 (0.40) | HRH3DRD2HTR2AHTR2CKCNH2 | |
| SCHEMBL22669108 | 0.78 | HRH3 (0.35) | HRH3KCNH2MEN1KMT2A | |
| SCHEMBL22668925 | 0.78 | ENPP2 (0.38) | HRH3DRD2HTR2AHTR2CKCNH2 | |
| SCHEMBL22668920 | 0.77 | HRH3 (0.68) | HRH3KCNH2 | |
| SCHEMBL22668852 | 0.77 | HRH3 (0.44) | HRH3MAOB | |
| SCHEMBL22669020 | 0.75 | HRH3 (0.43) | HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020229968-A1 | NON-LYSOSOMAL GLUCOSYLCERAMIDASE INHIBITORS AND USES THEREOF | ALECTOS THERAPEUTICS INC. (CA) | 2020-11-19 | — | — | WO | disclosed |