Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 14/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.39 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22668864 | 0.92 | SIGMAR1 (0.40) | HRH3KCNH2OPRM1OPRD1OPRK1 | |
| SCHEMBL23996602 | 0.83 | SPHK1 (0.51) | SPHK1 | |
| SCHEMBL14660575 | 0.80 | GBA1 (0.52) | HRH3 | |
| SCHEMBL4513431 | 0.80 | GBA1 (0.52) | HRH3 | |
| SCHEMBL22668719 | 0.80 | GBA1 (0.52) | HRH3 | |
| SCHEMBL22668731 | 0.76 | HRH3 (0.53) | HRH3KCNH2 | |
| SCHEMBL22668915 | 0.76 | HRH3 (0.67) | HRH3KCNH2OPRM1OPRD1OPRK1 | |
| SCHEMBL8661099 | 0.75 | HRH3 (0.46) | HRH3KCNH2 | |
| SCHEMBL22669020 | 0.75 | HRH3 (0.43) | HRH3KCNH2 | |
| SCHEMBL22669022 | 0.73 | HRH3 (0.52) | HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020229968-A1 | NON-LYSOSOMAL GLUCOSYLCERAMIDASE INHIBITORS AND USES THEREOF | ALECTOS THERAPEUTICS INC. (CA) | 2020-11-19 | — | — | WO | disclosed |